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Scientific article
English

Copper-catalyzed kinetic resolution of 1,3-cyclohexadiene monoepoxide with Grignard reagents

Published inSynlett, no. 3, p. 435-438
Publication date2007
Abstract

Chiral ferrocenyl-based diphosphines lead to kinetic resolution of 1,3-cyclohexadiene monoepoxide with moderate to good enantioselectivity (up to 90% ee) and good regioselectivity with various Grignard reagents through an anti-SN2¢ pathway.

Keywords
  • Epoxides
  • Asymmetric synthesis
  • Grignard reagents
  • Catalysis
  • Copper
Citation (ISO format)
MILLET, Renaud, ALEXAKIS, Alexandre. Copper-catalyzed kinetic resolution of 1,3-cyclohexadiene monoepoxide with Grignard reagents. In: Synlett, 2007, n° 3, p. 435–438. doi: 10.1055/s-2007-967945
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0936-5214
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