Copper-catalyzed kinetic resolution of 1,3-cyclohexadiene monoepoxide with Grignard reagents

Millet, Renaud; Alexakis, Alexandre

doi:10.1055/s-2007-967945

Scientific article

English

Copper-catalyzed kinetic resolution of 1,3-cyclohexadiene monoepoxide with Grignard reagents

Contributors

Millet, Renaud; Alexakis, Alexandre

Published in

Synlett, no. 3, p. 435-438

Publication date

2007

Abstract

Chiral ferrocenyl-based diphosphines lead to kinetic resolution of 1,3-cyclohexadiene monoepoxide with moderate to good enantioselectivity (up to 90% ee) and good regioselectivity with various Grignard reagents through an anti-SN2¢ pathway.

Keywords

Epoxides
Asymmetric synthesis
Grignard reagents
Catalysis
Copper

UNIGE affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

MILLET, Renaud, ALEXAKIS, Alexandre. Copper-catalyzed kinetic resolution of 1,3-cyclohexadiene monoepoxide with Grignard reagents. In: Synlett, 2007, n° 3, p. 435–438. doi: 10.1055/s-2007-967945

Article (Published version)

Identifiers

PID : unige:8027
DOI : 10.1055/s-2007-967945

Journal ISSN

0936-5214

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21/06/2010 14:15:42

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21/06/2010 14:15:42

Update

14/03/2023 15:47:45

Status update

14/03/2023 15:47:45

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10/06/2025 21:35:38

Copper-catalyzed kinetic resolution of 1,3-cyclohexadiene monoepoxide with Grignard reagents

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation