Copper-catalyzed kinetic resolution of 1,3-cyclohexadiene monoepoxide with Grignard reagents

Millet, Renaud; Alexakis, Alexandre

doi:10.1055/s-2007-967945

Scientific article

English

Copper-catalyzed kinetic resolution of 1,3-cyclohexadiene monoepoxide with Grignard reagents

ContributorsMillet, Renaud; Alexakis, Alexandre

Published inSynlett, no. 3, p. 435-438

Publication date2007

Abstract

Chiral ferrocenyl-based diphosphines lead to kinetic resolution of 1,3-cyclohexadiene monoepoxide with moderate to good enantioselectivity (up to 90% ee) and good regioselectivity with various Grignard reagents through an anti-SN2¢ pathway.

Keywords

Epoxides
Asymmetric synthesis
Grignard reagents
Catalysis
Copper

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

MILLET, Renaud, ALEXAKIS, Alexandre. Copper-catalyzed kinetic resolution of 1,3-cyclohexadiene monoepoxide with Grignard reagents. In: Synlett, 2007, n° 3, p. 435–438. doi: 10.1055/s-2007-967945

Article (Published version)

Identifiers

PID : unige:8027
DOI : 10.1055/s-2007-967945

Journal ISSN0936-5214

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Copper-catalyzed kinetic resolution of 1,3-cyclohexadiene monoepoxide with Grignard reagents

Chiral ferrocenyl-based diphosphines lead to kinetic resolution of 1,3-cyclohexadiene monoepoxide with moderate to good enantioselectivity (up to 90% ee) and good regioselectivity with various Grignard reagents through an anti-SN2¢ pathway.

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