• Home
  1. Home
  2. Enantioselective copper catalysed conjugate addition to 2- or 3- substituted cyclopent-2-ene-1-ones: Construction of stereogenic quaternary carbon centers
Scientific article
Letter
English

Enantioselective copper catalysed conjugate addition to 2- or 3- substituted cyclopent-2-ene-1-ones: Construction of stereogenic quaternary carbon centers

Contributors

Vuagnoux-D'Augustin De, Magali; Kehrli, Stefan; Alexakis, Alexandre

Published in

Synlett, no. 13, p. 2057-2060

Publication date

2007

Abstract

Trimethyl- and triethylaluminum undergo enantioselective conjugate addition to 2- and 3-substituted cyclopent-2-en-1- ones in the presence of catalytic amount of a copper salt and a phosphoramidite or a diphosphite ligand. Thus, chiral quaternary centers can be built with up to 93% ee.

Keywords

  • Aluminum
  • Copper
  • Michael addition
  • Asymmetric catalysis
  • Ligands

UNIGE affiliation entities

Citation (ISO format)

VUAGNOUX-D’AUGUSTIN DE, Magali, KEHRLI, Stefan, ALEXAKIS, Alexandre. Enantioselective copper catalysed conjugate addition to 2- or 3- substituted cyclopent-2-ene-1-ones: Construction of stereogenic quaternary carbon centers. In: Synlett, 2007, n° 13, p. 2057–2060. doi: 10.1055/s-2007-984889

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0936-5214
580views
0downloads

Technical informations

Creation

21/06/2010 14:15:42

First validation

21/06/2010 14:15:42

Update

14/03/2023 15:47:45

Status update

14/03/2023 15:47:45

Last indexation

10/06/2025 21:35:36
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated