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Enantioselective copper catalysed conjugate addition to 2- or 3- substituted cyclopent-2-ene-1-ones: Construction of stereogenic quaternary carbon centers

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Published in Synlett. 2007, no. 13, p. 2057-2060
Abstract Trimethyl- and triethylaluminum undergo enantioselective conjugate addition to 2- and 3-substituted cyclopent-2-en-1- ones in the presence of catalytic amount of a copper salt and a phosphoramidite or a diphosphite ligand. Thus, chiral quaternary centers can be built with up to 93% ee.
Keywords AluminumCopperMichael additionAsymmetric catalysisLigands
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VUAGNOUX-D'AUGUSTIN DE, Magali, KEHRLI, Stefan, ALEXAKIS, Alexandre. Enantioselective copper catalysed conjugate addition to 2- or 3- substituted cyclopent-2-ene-1-ones: Construction of stereogenic quaternary carbon centers. In: Synlett, 2007, n° 13, p. 2057-2060. https://archive-ouverte.unige.ch/unige:8026

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Deposited on : 2010-06-21

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