Enantioselective copper catalysed conjugate addition to 2- or 3- substituted cyclopent-2-ene-1-ones: Construction of stereogenic quaternary carbon centers

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Title		Enantioselective copper catalysed conjugate addition to 2- or 3- substituted cyclopent-2-ene-1-ones: Construction of stereogenic quaternary carbon centers
Authors		Vuagnoux-D'Augustin De, Magali Kehrli, Stefan Alexakis, Alexandre
Published in		Synlett. 2007, no. 13, p. 2057-2060
Abstract		Trimethyl- and triethylaluminum undergo enantioselective conjugate addition to 2- and 3-substituted cyclopent-2-en-1- ones in the presence of catalytic amount of a copper salt and a phosphoramidite or a diphosphite ligand. Thus, chiral quaternary centers can be built with up to 93% ee.
Keywords		Aluminum — Copper — Michael addition — Asymmetric catalysis — Ligands
Identifiers		DOI: 10.1055/s-2007-984889
Full text		Article (Published version) - Limited access to UNIGE
Structures		Faculté des sciences / Section de chimie et biochimie / Département de chimie organique
Citation (ISO format)		VUAGNOUX-D'AUGUSTIN DE, Magali, KEHRLI, Stefan, ALEXAKIS, Alexandre. Enantioselective copper catalysed conjugate addition to 2- or 3- substituted cyclopent-2-ene-1-ones: Construction of stereogenic quaternary carbon centers. In: Synlett, 2007, n° 13, p. 2057-2060. doi: 10.1055/s-2007-984889 https://archive-ouverte.unige.ch/unige:8026