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New insights into the mechanisms underlying the UVR8 signaling cascade using yeast and plant systems

ContributorsPodolec, Romanorcid
DirectorsUlm, Romanorcid
Master program titleMaster en Biologie orientation Molecular Plant Sciences (MPS)
Defense date2016
Abstract

UV-B, as a component of sunlight, has potentially damaging effects on biomolecules and triggers a photomorphogenic response in plants. UV-B is perceived by UV RESISTANCE LOCUS 8 (UVR8), a β-propeller protein converted from homodimer to monomer upon UV-B absorption. This structural change triggers a signal transduction pathway when the monomer interacts with CONSTITUTIVE PHOTOMORPHOGENESIS 1 (COP1), leading to transcriptional reprogramming mediated by the transcription factor ELONGATED HYPOCOTYL 5 (HY5). Two of the early induced genes encode REPRESSOR OF UV-B PHOTOMORPHOGENESIS 1 (RUP1) and RUP2, which promote UVR8 reversion from monomer to dimer. SUPPRESSOR OF phyA-101 (SPA) proteins form a complex with COP1 that is stable under UV-B, yet they associate only indirectly, through COP1, with UVR8. In this work, several aspects of UVR8-mediated UV-B signaling were investigated, providing new tools and new insights into the mechanisms underlying the UVR8 signaling pathway, which will be of use for future investigations.

eng
Keywords
  • UV-B
  • Arabidopsis
  • UVR8
  • COP1
  • RUP1
  • RUP2
Research group
Citation (ISO format)
PODOLEC, Roman. New insights into the mechanisms underlying the UVR8 signaling cascade using yeast and plant systems. 2016.
Main files (1)
Master thesis
accessLevelRestricted
Identifiers
  • PID : unige:80250
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Creation02/01/2016 4:46:00 PM
First validation02/01/2016 4:46:00 PM
Update time03/15/2023 12:06:59 AM
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