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Title

How somatic adult tissues develop organizer activity
Authors
Vogg, Matthias Christian
Wenger, Yvan
Galliot, Brigitte
Published in Current Topics in Developmental Biology. 2016, vol. 96
Abstract The growth and patterning of anatomical structures from specific cellular fields in developing organisms relies on organizing centers that instruct surrounding cells to modify their behavior, namely migration, proliferation, and differentiation. We discuss here how organizers can form in adult organisms, a process of utmost interest for regenerative medicine. Animals like Hydra and planarians, which maintain their shape and fitness thanks to a highly dynamic homeostasis, offer a useful paradigm to study adult organizers in steady-state conditions. Beside the homeostatic context, these model systems also offer the possibility to study how organizers form de novo from somatic adult tissues. Both extracellular matrix remodeling and caspase activation play a key role in this transition, acting as promoters of organizer formation in the vicinity of the wound. Their respective roles and the crosstalk between them just start to be deciphered.
Keywords Hydra — Planaria — De novo organizer formation — Blastema — Adult tissues — Homeostasis — Regeneration — Wnt signaling — Model systems
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Other version: http://www.sciencedirect.com/science/article/pii/S0070215315001210
Structures
Faculté des sciences / Section de biologie / Département de génétique et évolution
Research group Groupe Galliot
Projects FNS: SNF 31003A_149630
NIH R01AG037962
Citation
(ISO format) 		VOGG, Matthias Christian, WENGER, Yvan, GALLIOT, Brigitte. How somatic adult tissues develop organizer activity. In: Current Topics in Developmental Biology, 2016, vol. 96. https://archive-ouverte.unige.ch/unige:80139

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Deposited on : 2016-02-01

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