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Title

The Nucleoprotein Is Required for Lymphocytic Choriomeningitis Virus-Based Vaccine Vector Immunogenicity

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Published in Journal of Virology. 2015, vol. 89, no. 22, p. 11734-11738
Abstract Recombinant glycoprotein-deficient lymphocytic choriomeningitis virus-based vaccine vectors (rLCMV/ΔGP) are potent CD8(+) T cell inducers. To investigate the underlying molecular requirements, we generated a nucleoprotein-deficient vector counterpart (rLCMV/ΔNP). NP but not GP is a minimal trans-acting factor for viral transcription and genome replication. We found that, unlike rLCMV/ΔGP, rLCMV/ΔNP failed to elicit detectable CD8(+) T cell responses unless NP was trans complemented in a transgenic host. Hence, NP-dependent intracellular gene expression is essential for LCMV vector immunogenicity.
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PMID: 26355095
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Article (Published version) (318 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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DARBRE, Stéphanie et al. The Nucleoprotein Is Required for Lymphocytic Choriomeningitis Virus-Based Vaccine Vector Immunogenicity. In: Journal of Virology, 2015, vol. 89, n° 22, p. 11734-11738. https://archive-ouverte.unige.ch/unige:80105

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Deposited on : 2016-01-28

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