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Transcriptional regulators of the UV-B signaling pathway in Arabidopsis thaliana

Defense Thèse de doctorat : Univ. Genève, 2015 - Sc. 4878 - 2015/12/21
Abstract UV-B perception by the photoreceptor UVR8 initiates a signaling cascade that leads to UV-B acclimation. Several components of the UV-B signaling pathway have been identified and characterized in the last decade and significant insight into the perception mechanism was obtained. However, our understanding on how UV-B photoreception by UVR8 leads to transcriptional changes is far from being coherent and complete. UV-B signal transduction within the UV-B signaling pathway involves the interaction of photoactivated UVR8 with its signaling partner COP1 and an activity of the transcription factor HY5 at UV-B-responsive promoters. In this work I aimed to gain insight into the molecular events bridging the gap from UVR8-COP1 interaction to HY5-mediated UV-B-responsive gene expression. I addressed the following questions: 1) How does HY5 regulate gene expression in response to UV-B? 2) Is there a function of UVR8 at the chromatin level? 3) What other proteins are regulating UVR8-COP1-mediated UV-B signaling pathway?
Keywords UV-BArabidopsis thalianaSignaling pathwayTranscriptional regulatorsUVR8HY5Chromatin
URN: urn:nbn:ch:unige-796802
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Research group Groupe Ulm
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BINKERT, Melanie. Transcriptional regulators of the UV-B signaling pathway in Arabidopsis thaliana. Université de Genève. Thèse, 2015. doi: 10.13097/archive-ouverte/unige:79680 https://archive-ouverte.unige.ch/unige:79680

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