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Rapid memory stabilization by transient theta coherence in the human medial temporal lobe

Published inHippocampus, vol. 26, p. 445-454
Publication date2016
Abstract

Presenting stimuli again after presentation of intervening stimuli improves their retention, an effect known as the spacing effect. However, using event-related potentials (ERPs), we had observed that immediate, in comparison to spaced, repetition of pictures induced a positive frontal potential at 200-300 ms. This potential appeared to emanate from the left medial temporal lobe (MTL), a structure critical for memory consolidation. In this study, we tested the behavioral relevance of this signal and explored functional connectivity changes during picture repetition. We obtained high-density electroencephalographic recordings from 14 healthy subjects performing a continuous recognition task where pictures were either repeated immediately or after 9 intervening items. Conventional ERP analysis replicated the positive frontal potential emanating from the left MTL at 250-350 ms in response to immediately repeated stimuli. Connectivity analysis showed that this ERP was associated with increased coherence in the MTL region-left more that right-in the theta-band (3.5-7 Hz) 200-400 ms following immediate, but not spaced, repetition. This increase was stronger in subjects who better recognized immediately repeated stimuli after 30 min. These findings indicate that transient theta-band synchronization between the MTL and the rest of the brain at 200-400 ms reflects a memory stabilizing signal. © 2015 Wiley Periodicals, Inc.

Citation (ISO format)
THÉZÉ, Raphaël et al. Rapid memory stabilization by transient theta coherence in the human medial temporal lobe. In: Hippocampus, 2016, vol. 26, p. 445–454. doi: 10.1002/hipo.22534
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ISSN of the journal1050-9631
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