The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis

Vermeij, Eline A; Koenders, Marije I; Bennink, Miranda B; Crowe, Lindsey; Maurizi, Lionel; Vallée, Jean-Paul; Hofmann, Heinrich; van den Berg, Wim B; van Lent, Peter L E M; van de Loo, Fons A J

doi:10.1371/journal.pone.0126687

Scientific article

Open access

English

The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis

ContributorsVermeij, Eline A; Koenders, Marije I; Bennink, Miranda B; Crowe, Lindsey; Maurizi, Lionel; Vallée, Jean-Paul

; Hofmann, Heinrich; van den Berg, Wim B; van Lent, Peter L E M; van de Loo, Fons A J

Published inPloS one, vol. 10, no. 5, e0126687

Publication date2015

Abstract

Superparamagnetic Iron Oxide Nanoparticles (SPION) are used in diagnostic imaging of a variety of different diseases. For such in-vivo application, an additional coating with a polymer, for example polyvinyl alcohol (PVA), is needed to stabilize the SPION and prevent aggregation. As the particles are foreign to the body, reaction against the SPION could occur. In this study we investigated the effects that SPION may have on experimental arthritis after intra-articular (i.a.) or intravenous (i.v.) injection.

Affiliation

Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Research group

Imagerie cardiaque fonctionnelle (541)

Citation (ISO format)

VERMEIJ, Eline A et al. The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis. In: PloS one, 2015, vol. 10, n° 5, p. e0126687. doi: 10.1371/journal.pone.0126687

Article (Published version)

CC BY

Identifiers

PID : unige:79641
DOI : 10.1371/journal.pone.0126687
PMID : 25955417

ISSN of the journal1932-6203

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The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis

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