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Scientific article
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English

The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis

Published inPloS one, vol. 10, no. 5, e0126687
Publication date2015
Abstract

Superparamagnetic Iron Oxide Nanoparticles (SPION) are used in diagnostic imaging of a variety of different diseases. For such in-vivo application, an additional coating with a polymer, for example polyvinyl alcohol (PVA), is needed to stabilize the SPION and prevent aggregation. As the particles are foreign to the body, reaction against the SPION could occur. In this study we investigated the effects that SPION may have on experimental arthritis after intra-articular (i.a.) or intravenous (i.v.) injection.

Citation (ISO format)
VERMEIJ, Eline A et al. The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis. In: PloS one, 2015, vol. 10, n° 5, p. e0126687. doi: 10.1371/journal.pone.0126687
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ISSN of the journal1932-6203
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Creation11/16/2015 3:05:00 PM
First validation11/16/2015 3:05:00 PM
Update time03/15/2023 12:04:26 AM
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