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Title

Interaction Between Hippocampus and Cerebellum Crus I in Sequence-Based but not Place-Based Navigation

Authors
Doeller, Christian F
Paradis, Anne-Lise
Benchenane, Karim
Berthoz, Alain
Burgess, Neil
Rondi-Reig, Laure
Published in Cerebral Cortex. 2015, vol. 25, no. 11, p. 4146-4154
Abstract To examine the cerebellar contribution to human spatial navigation we used functional magnetic resonance imaging and virtual reality. Our findings show that the sensory-motor requirements of navigation induce activity in cerebellar lobules and cortical areas known to be involved in the motor loop and vestibular processing. By contrast, cognitive aspects of navigation mainly induce activity in a different cerebellar lobule (VIIA Crus I). Our results demonstrate a functional link between cerebellum and hippocampus in humans and identify specific functional circuits linking lobule VIIA Crus I of the cerebellum to medial parietal, medial prefrontal, and hippocampal cortices in nonmotor aspects of navigation. They further suggest that Crus I belongs to 2 nonmotor loops, involved in different strategies: place-based navigation is supported by coherent activity between left cerebellar lobule VIIA Crus I and medial parietal cortex along with right hippocampus activity, while sequence-based navigation is supported by coherent activity between right lobule VIIA Crus I, medial prefrontal cortex, and left hippocampus. These results highlight the prominent role of the human cerebellum in both motor and cognitive aspects of navigation, and specify the cortico-cerebellar circuits by which it acts depending on the requirements of the task.
Keywords fMRIFunctional connectivitySequence learningSpatial memoryVirtual reality
Identifiers
PMID: 24947462
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Article (Published version) (716 Kb) - public document Free access
Structures
Research groups Affective sciences
Neuroimagerie du Sommeil et de la Cognition (832)
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(ISO format)
IGLOI, Kinga Katinka et al. Interaction Between Hippocampus and Cerebellum Crus I in Sequence-Based but not Place-Based Navigation. In: Cerebral Cortex, 2015, vol. 25, n° 11, p. 4146-4154. https://archive-ouverte.unige.ch/unige:79607

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Deposited on : 2016-01-19

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