Neopterin plasma concentrations in patients with aneurysmal subarachnoid hemorrhage: correlation with infection and long-term outcome

Azurmendi Gil, Leire; Degos, Vincent; Tiberti, Natalia; Kapandji, Natacha; Sanchez-Peña, Paola; Sarrafzadeh, Asita; Puybasset, Louis; Turck, Natacha; Sanchez, Jean-Charles

Advanced search

Browse by...

Deposit

Highlights

More informations

Title		Neopterin plasma concentrations in patients with aneurysmal subarachnoid hemorrhage: correlation with infection and long-term outcome
Authors		Azurmendi Gil, Leire Degos, Vincent Tiberti, Natalia Kapandji, Natacha Sanchez-Peña, Paola Sarrafzadeh, Asita Puybasset, Louis Turck, Natacha Sanchez, Jean-Charles show all authors [1 - 9]
Published in		Journal of Neurosurgery. 2015, p. 1-13
Abstract		OBJECT Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high rates of mortality and morbidity. The main predictor for the poor outcome is the World Federation of Neurosurgical Societies (WFNS) scale. However, this scale does not take into account proinflammatory events, such as infection occurring after the aSAH, which could modify the long-term status of patients. The aim of this study was to evaluate neopterin as an inflammatory biomarker for outcome and infection prediction in aSAH patients. METHODS Plasma concentrations of neopterin were measured in 61 aSAH patients (22 male and 39 female; mean age [± SD] 52.8 ± 11.8 years) using a commercial ELISA kit. Samples were collected daily for 10 days. Outcome at 12 months was determined using the Glasgow Outcome Scale (GOS) and dichotomized as poor (GOS score 1, 2, or 3) or good (GOS score 4 or 5). Infection was determined by the presence of a positive bacterial culture. RESULTS Patients with poor outcome at 12 months had higher concentrations of neopterin than patients with good outcome. In the same way, patients who had an infection during the hospitalization had significantly higher concentrations of neopterin than patients without infection (p = 0.001). Moreover, neopterin concentrations were significantly (p < 0.008) elevated in infected patients 2 days before infection detection and antibiotic therapy. CONCLUSIONS Neopterin is an efficient outcome predictor after aSAH. Furthermore, it is able to differentiate between infected and uninfected patients as early as 2 days before clinical signs of infection, facilitating earlier antibiotic therapy and better management.
Identifiers		DOI: 10.3171/2015.3.JNS142212 PMID: 26406798
Full text		Article (Published version) (5.7 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research groups		Groupe de Protéomique biomédicale (635) Omics Panels of Tears Indicators for ocular and systemic Clinical Situations (957)
Citation (ISO format)		AZURMENDI GIL, Leire et al. Neopterin plasma concentrations in patients with aneurysmal subarachnoid hemorrhage: correlation with infection and long-term outcome. In: Journal of Neurosurgery, 2015, p. 1-13. https://archive-ouverte.unige.ch/unige:79589