en
Scientific article
Open access
English

Mismatches in Influenza A virus vRNA panhandle prevent RIG-I sensing by impairing RNA/RIG-I complex formation

Published inJournal of virology, vol. 90, no. 1, p. 586-590
Publication date2016
Abstract

Influenza virus RNA promoter panhandle structures are believed to be sensed by RIG-I. The occurrence of mismatches in this dsRNA structure raises questions about their effect on innate sensing. Our results suggest that mismatches in vRNA promoters decrease binding to RIG-I in vivo, affecting RNA/RIG-I complex formation, and preventing RIG-I activation. These results can be inferred to apply to other viruses and suggest that mismatches may represent a general viral strategy to escape RIG-I sensing.

Citation (ISO format)
ANCHISI, Stéphanie et al. Mismatches in Influenza A virus vRNA panhandle prevent RIG-I sensing by impairing RNA/RIG-I complex formation. In: Journal of virology, 2016, vol. 90, n° 1, p. 586–590. doi: 10.1128/JVI.01671-15
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0022-538X
536views
179downloads

Technical informations

Creation10/22/2015 3:55:00 PM
First validation10/22/2015 3:55:00 PM
Update time03/15/2023 12:03:48 AM
Status update03/15/2023 12:03:48 AM
Last indexation01/16/2024 8:01:41 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack