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Mismatches in Influenza A virus vRNA panhandle prevent RIG-I sensing by impairing RNA/RIG-I complex formation

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Published in Journal of Virology. 2015
Abstract Influenza virus RNA promoter panhandle structures are believed to be sensed by RIG-I. The occurrence of mismatches in this dsRNA structure raises questions about their effect on innate sensing. Our results suggest that mismatches in vRNA promoters decrease binding to RIG-I in vivo, affecting RNA/RIG-I complex formation, and preventing RIG-I activation. These results can be inferred to apply to other viruses and suggest that mismatches may represent a general viral strategy to escape RIG-I sensing.
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PMID: 26446607
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Article (Published version) (1 MB) - public document Free access
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Research group Virologie moléculaire (275)
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ANCHISI, Stéphanie et al. Mismatches in Influenza A virus vRNA panhandle prevent RIG-I sensing by impairing RNA/RIG-I complex formation. In: Journal of Virology, 2015. https://archive-ouverte.unige.ch/unige:79563

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Deposited on : 2016-01-19

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