Hydrophilic Anchors for Transmembrane Anion-π Slides

Gorteau, Virginie; Julliard, Marc D.; Matile, Stefan

doi:10.1016/j.memsci.2007.10.040

Scientific article

English

Hydrophilic Anchors for Transmembrane Anion-π Slides

ContributorsGorteau, Virginie; Julliard, Marc D.; Matile, Stefan

Published inJournal of membrane science, vol. 321, no. 1, p. 37-42

Publication date2008

Abstract

The concept of hydrophilic anchoring is introduced to activate rigid oligonaphthalenediimide (O-NDI) rods as anion–p slides for multi-ion hopping across lipid bilayers. We report that short peptide solubilizers suffice to reach the rare combination of high activity and high selectivity that is needed for anion pumping in vesicles.

Keywords

Ion channels
Solubility
Hydrophilicity
Amphiphilicity
Lipid bilayer membrane
Partitioning
Transport assays
Anion selectivity
Anion–p interactions
Multi-ion hopping

Affiliation

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

GORTEAU, Virginie, JULLIARD, Marc D., MATILE, Stefan. Hydrophilic Anchors for Transmembrane Anion-π Slides. In: Journal of membrane science, 2008, vol. 321, n° 1, p. 37–42. doi: 10.1016/j.memsci.2007.10.040

Article

Identifiers

PID : unige:7955
DOI : 10.1016/j.memsci.2007.10.040

ISSN of the journal0376-7388

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Hydrophilic Anchors for Transmembrane Anion-π Slides

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