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Synthesis and Investigation of Tryptophan-Amphotericin B Conjugates |
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Published in | ChemBioChem. 2009, vol. 10, no. 10, p. 1617-1620 | |
Abstract | Anchors aweigh! The synthesis of tryptophan-amphotericin B conjugates (see figure) is described. The membrane-anchoring effect of tryptophane was thus combined with the pore-formation effect of amphotericin B leading to high channel activity in sterol-free liposomes. | |
Keywords | Amphotericin B — Bioorganic chemistry — Ion-selective electrodes — Membranes — Tryptophan | |
Identifiers | PMID: 19533712 | |
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Citation (ISO format) | ZUMBUEHL, Andréas et al. Synthesis and Investigation of Tryptophan-Amphotericin B Conjugates. In: ChemBioChem, 2009, vol. 10, n° 10, p. 1617-1620. doi: 10.1002/cbic.200900096 https://archive-ouverte.unige.ch/unige:7938 |