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Title

Synthesis and Investigation of Tryptophan-Amphotericin B Conjugates
Authors
Zumbuehl, Andréas
Stano, Pasquale
Sohrmann, Marc
Dietiker, Rolf
Peter, Mathias
Carreira, Erick M.
Published in ChemBioChem. 2009, vol. 10, no. 10, p. 1617-1620
Abstract Anchors aweigh! The synthesis of tryptophan-amphotericin B conjugates (see figure) is described. The membrane-anchoring effect of tryptophane was thus combined with the pore-formation effect of amphotericin B leading to high channel activity in sterol-free liposomes.
Keywords Amphotericin B — Bioorganic chemistry — Ion-selective electrodes — Membranes — Tryptophan
Identifiers
PMID: 19533712
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Article - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté des sciences / Section de chimie et biochimie / Département de chimie organique
Citation
(ISO format) 		ZUMBUEHL, Andréas et al. Synthesis and Investigation of Tryptophan-Amphotericin B Conjugates. In: ChemBioChem, 2009, vol. 10, n° 10, p. 1617-1620. doi: 10.1002/cbic.200900096 https://archive-ouverte.unige.ch/unige:7938

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Deposited on : 2010-06-21

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