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Title

Synthesis and Investigation of Tryptophan-Amphotericin B Conjugates

Authors
Stano, Pasquale
Sohrmann, Marc
Dietiker, Rolf
Peter, Mathias
Carreira, Erick M.
Published in ChemBioChem. 2009, vol. 10, no. 10, p. 1617-1620
Abstract Anchors aweigh! The synthesis of tryptophan-amphotericin B conjugates (see figure) is described. The membrane-anchoring effect of tryptophane was thus combined with the pore-formation effect of amphotericin B leading to high channel activity in sterol-free liposomes.
Keywords Amphotericin BBioorganic chemistryIon-selective electrodesMembranesTryptophan
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PMID: 19533712
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ZUMBUEHL, Andréas et al. Synthesis and Investigation of Tryptophan-Amphotericin B Conjugates. In: ChemBioChem, 2009, vol. 10, n° 10, p. 1617-1620. https://archive-ouverte.unige.ch/unige:7938

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Deposited on : 2010-06-21

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