Synthesis and Investigation of Tryptophan-Amphotericin B Conjugates

Zumbuehl, Andréas; Stano, Pasquale; Sohrmann, Marc; Dietiker, Rolf; Peter, Mathias; Carreira, Erick M.

doi:10.1002/cbic.200900096

Scientific article

English

Synthesis and Investigation of Tryptophan-Amphotericin B Conjugates

ContributorsZumbuehl, Andréas; Stano, Pasquale; Sohrmann, Marc; Dietiker, Rolf; Peter, Mathias; Carreira, Erick M.

Published inChemBioChem, vol. 10, no. 10, p. 1617-1620

Publication date2009

Abstract

Anchors aweigh! The synthesis of tryptophan-amphotericin B conjugates (see figure) is described. The membrane-anchoring effect of tryptophane was thus combined with the pore-formation effect of amphotericin B leading to high channel activity in sterol-free liposomes.

Keywords

Amphotericin B
Bioorganic chemistry
Ion-selective electrodes
Membranes
Tryptophan

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

ZUMBUEHL, Andréas et al. Synthesis and Investigation of Tryptophan-Amphotericin B Conjugates. In: ChemBioChem, 2009, vol. 10, n° 10, p. 1617–1620. doi: 10.1002/cbic.200900096

Article (Published version)

Identifiers

PID : unige:7938
DOI : 10.1002/cbic.200900096
PMID : 19533712

Journal ISSN1439-4227

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Synthesis and Investigation of Tryptophan-Amphotericin B Conjugates

Anchors aweigh! The synthesis of tryptophan-amphotericin B conjugates (see figure) is described. The membrane-anchoring effect of tryptophane was thus combined with the pore-formation effect of amphotericin B leading to high channel activity in sterol-free liposomes.

Technical informations