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Title

Enantioselective Iridium-catalysed allylic arylation
Authors
Polet, Damien
Rathgeb, Xavier
Falciola, Caroline Alexandra
Langlois, Jean-Baptiste
El Hajjaji, Samir
Alexakis, Alexandre
Published in Chemistry. 2009, vol. 15, no. 5, p. 1205-1216
Abstract We describe herein the development of the first iridium-catalyzed allylic substitution using arylzinc nucleophiles. High enantioselectivities were obtained from the reactions, which used commercially available Grignard reagents as the starting materials. This methodology was also shown to be compatible with halogen/metal exchange reactions. Its synthetic potential is demonstrated by its application towards the formal synthesis of (+)-sertraline.
Keywords Allylic substitution — Asymmetric catalysis — Chiral ligands — Cross-coupling — Iridium
Identifiers
PMID: 19072966
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Structures
Faculté des sciences / Section de chimie et biochimie / Département de chimie organique
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(ISO format) 		POLET, Damien et al. Enantioselective Iridium-catalysed allylic arylation. In: Chemistry, 2009, vol. 15, n° 5, p. 1205-1216. doi: 10.1002/chem.200801879 https://archive-ouverte.unige.ch/unige:7937

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Deposited on : 2010-06-21

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