en
Scientific article
English

Enantioselective Iridium-catalysed allylic arylation

Published inChemistry, vol. 15, no. 5, p. 1205-1216
Publication date2009
Abstract

We describe herein the development of the first iridium-catalyzed allylic substitution using arylzinc nucleophiles. High enantioselectivities were obtained from the reactions, which used commercially available Grignard reagents as the starting materials. This methodology was also shown to be compatible with halogen/metal exchange reactions. Its synthetic potential is demonstrated by its application towards the formal synthesis of (+)-sertraline.

Keywords
  • Allylic substitution
  • Asymmetric catalysis
  • Chiral ligands
  • Cross-coupling
  • Iridium
Citation (ISO format)
POLET, Damien et al. Enantioselective Iridium-catalysed allylic arylation. In: Chemistry, 2009, vol. 15, n° 5, p. 1205–1216. doi: 10.1002/chem.200801879
Main files (1)
Article
accessLevelRestricted
Identifiers
ISSN of the journal0947-6539
572views
0downloads

Technical informations

Creation06/21/2010 10:28:48 AM
First validation06/21/2010 10:28:48 AM
Update time03/14/2023 3:47:22 PM
Status update03/14/2023 3:47:21 PM
Last indexation02/12/2024 6:45:15 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack