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Title

Enantioselective Iridium-catalysed allylic arylation

Authors
El Hajjaji, Samir
Published in Chemistry - A European Journal. 2009, vol. 15, no. 5, p. 1205-1216
Abstract We describe herein the development of the first iridium-catalyzed allylic substitution using arylzinc nucleophiles. High enantioselectivities were obtained from the reactions, which used commercially available Grignard reagents as the starting materials. This methodology was also shown to be compatible with halogen/metal exchange reactions. Its synthetic potential is demonstrated by its application towards the formal synthesis of (+)-sertraline.
Keywords Allylic substitutionAsymmetric catalysisChiral ligandsCross-couplingIridium
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PMID: 19072966
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POLET, Damien et al. Enantioselective Iridium-catalysed allylic arylation. In: Chemistry - A European Journal, 2009, vol. 15, n° 5, p. 1205-1216. https://archive-ouverte.unige.ch/unige:7937

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Deposited on : 2010-06-21

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