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Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection

Published inLancet neurology, vol. 14, no. 6, p. 640-654
Publication date2015
Abstract

Spontaneous intracranial artery dissection is an uncommon and probably underdiagnosed cause of stroke that is defi ned by the occurrence of a haematoma in the wall of an intracranial artery. Patients can present with headache, ischaemic stroke, subarachnoid haemorrhage, or symptoms associated with mass eff ect, mostly on the brainstem. Although intracranial artery dissection is less common than cervical artery dissection in adults of European ethnic origin, intracranial artery dissection is reportedly more common in children and in Asian populations. Risk factors and mechanisms are poorly understood, and diagnosis is challenging because characteristic imaging features can be diffi cult to detect in view of the small size of intracranial arteries. Therefore, multimodal follow-up imaging is often needed to confi rm the diagnosis. Treatment of intracranial artery dissections is empirical in the absence of data from randomised controlled trials. Most patients with subarachnoid haemorrhage undergo surgical or endovascular treatment to prevent rebleeding, whereas patients with intracranial artery dissection and cerebral ischaemia are treated with antithrombotics. Prognosis seems worse in patients with subarachnoid haemorrhage than in those without.

Citation (ISO format)
DEBETTE, Stéphanie, COMPTER, Annette, BIJLENGA, Philippe Alexandre Pierre. Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection. In: Lancet neurology, 2015, vol. 14, n° 6, p. 640–654. doi: 10.1016/S1474-4422(15)00009-5
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ISSN of the journal1474-4422
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