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"Dancing eye syndrome" secondary to opsoclonus-myoclonus syndrome in small-cell lung cancer

Laroumagne, S
Elharrar, Xavier
Coiffard, B
Dutau, H
Breen, D
Astoul, P
Published in Journal of Case Reports in Medicine. 2014, vol. 2014, p. 545490
Abstract Among paraneoplastic neurologic disorders (PND), opsoclonus-myoclonus syndrome, so-called "dancing eye syndrome," is a rare disorder combining multivectorial eye movements, involuntary multifocal myoclonus, and cerebellar ataxia. Although several paraneoplastic antibodies against postsynaptic or cell-surface antigens have been reported, usually most patients are serum antibody negative. We report a 65-year-old patient with opsoclonus-myoclonus syndrome revealing a small-cell lung carcinoma. If serologic antineuronal anti-body screening was negative, autoantibodies against glutamic acid decarboxylase (anti-GAD) were positive. Despite the specific anticancer treatment and high dose corticosteroids, the patient developed a severe and progressive encephalopathy and died 10 days later.
PMID: 24778658
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Research group Groupe Gasche-Soccal Paola (958)
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LAROUMAGNE, S et al. "Dancing eye syndrome" secondary to opsoclonus-myoclonus syndrome in small-cell lung cancer. In: Case Reports in Medicine, 2014, vol. 2014, p. 545490. doi: 10.1155/2014/545490 https://archive-ouverte.unige.ch/unige:79230

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Deposited on : 2016-01-13

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