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Synthetic peroxides as antimalarials

Contributeurs/tricesJefford, Charles
Publié dansCurrent opinion in investigational drugs, vol. 5, no. 8, p. 866-872
Date de publication2004
Résumé

This review describes the present status of purely synthetic peroxides and 1,2,4-trioxanes and how they perform in various preclinical tests as potential antimalarial drug candidates. The literature is reviewed from 1986 onwards, comprising mostly articles published in the last ten years. As several papers on antimalarial peroxides have already been published, this review focuses on more recent studies detailing the novelty and potential of synthetic peroxides.

Mots-clés
  • Arteflene
  • Bridged bicyclic peroxides
  • Chimerical molecules
  • 1,2-dioxanes
  • Formulation
  • In vitro activity
  • In vivo activity
  • Plasmodium
  • Resistance
  • 1,2,4,5-tetraoxanes
  • Toxicity
  • 1,2,4-trioxanes
Citation (format ISO)
JEFFORD, Charles. Synthetic peroxides as antimalarials. In: Current opinion in investigational drugs, 2004, vol. 5, n° 8, p. 866–872. doi: 10.1002/med.10066
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Article (Published version)
accessLevelRestricted
Identifiants
ISSN du journal1472-4472
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Informations techniques

Création21/06/2010 10:28:35
Première validation21/06/2010 10:28:35
Heure de mise à jour14/03/2023 15:47:16
Changement de statut14/03/2023 15:47:16
Dernière indexation15/01/2024 20:23:49
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