Ocular tolerance of absorption enhancers in ophthalmic preparations

Furrer, Pascal; Mayer, Joachim Michael; Plazonnet, Bernard; Gurny, Robert

doi:10.1208/ps040102

Scientific article

English

Ocular tolerance of absorption enhancers in ophthalmic preparations

Contributors

Furrer, Pascal; Mayer, Joachim Michael; Plazonnet, Bernard; Gurny, Robert

Published in

AAPS PharmSci, vol. 4, no. 1, p. 6-10

Publication date

2002

Abstract

The use of absorption promoters is a way to improve the bioavailability and therapeutic response of topically applied ophthalmic drugs. The ocular tolerance of 9 potential absorption promoters was investigated as well as the influence of the enhancers' concentration on the ocular tolerance. The substances tested were instillated repetitively (4 times per day, during 3 days, and once just before examination) as aqueous solutions onto rabbit corneas. Fluorescein dyeing enabled us to specifically mark corneal damage that was observed by confocal microscopy. The degree of corneal injury was assessed with an image-processing system that calculated the total fluorescent areas. Confocal microscopy results showed the relatively good tolerance of permeation enhancers like dimethyl sulfoxide (DMSO), decamethonium, edetate, glycocholate, and cholate in contrast to the poorly tolerated saponin and fusidate. Increasing the promoters' concentration led generally to an increase in corneal lesions.

Keywords

Ocular absorption
Permeation enhancers
Confocal microscopy
Toxicity

UNIGE affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

FURRER, Pascal et al. Ocular tolerance of absorption enhancers in ophthalmic preparations. In: AAPS PharmSci, 2002, vol. 4, n° 1, p. 6–10. doi: 10.1208/ps040102

Article (Published version)

Identifiers

PID : unige:79140
DOI : 10.1208/ps040102

Additional URL for this publication

http://link.springer.com/10.1208/ps040102

Journal ISSN

1522-1059

474views

1downloads

Creation

11/01/2016 08:21:00

First validation

11/01/2016 08:21:00

Update

15/03/2023 00:02:29

Status update

15/03/2023 00:02:28

Last indexation

31/10/2024 02:27:25

Ocular tolerance of absorption enhancers in ophthalmic preparations

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation