UNIGE document Scientific Article
previous document  unige:79139  next document
add to browser collection
Title

Delivery of antibiotics to the eye using a positively charged polysaccharide as vehicle

Authors
Published in AAPS PharmSci. 2001, vol. 3, no. 4, p. 87-93
Abstract The positively charged polysaccharide chitosan is able to increase precorneal residence time of ophthalmic formulations containing active compounds when compared with simple aqueous solutions. The purpose of the study was to evaluate tear concentration of tobramycin and ofloxacin after topical application of chitosan-based formulations containing 0.3% wt/vol of antibiotic and to compare them with 2 commercial solutions: Tobrex and Floxal, respectively. The influence of the molecular weight, deacetylation degree, and concentration of 4 different samples of chitosan on pharmacokinetic parameters (area under the curve values [AUC(eff)] and time of efficacy [t(eff)]) of tobramycin and ofloxacin in tears was investigated over time. It was demonstrated that the 2 chitosan products of high molecular weight (1350 and 1930 kd) and low deacetylation degree (50%) significantly increased antibiotic availability when compared to the controls, with AUC(eff) showing a 2- to 3-fold improvement. The time of efficacy of ofloxacin was significantly increased from about 25 minutes to 46 minutes by the chitosan of higher Mw (1930 kd) at a concentration of 0.5% wt/vol, whereas a similar performance was achieved by a chitosan of low Mw (580 kd) at a concentration of 1.5% wt/vol in the case of tobramycin.
Keywords ChitosanHydrogelOphthalmic applicationAntibioticPharmacokinetics
Identifiers
PMID: 12066799
Full text
Structures
Citation
(ISO format)
FELT-BAEYENS, Olivia et al. Delivery of antibiotics to the eye using a positively charged polysaccharide as vehicle. In: AAPS PharmSci, 2001, vol. 3, n° 4, p. 87-93. https://archive-ouverte.unige.ch/unige:79139

36 hits

0 download

Update

Deposited on : 2016-01-12

Export document
Format :
Citation style :