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Scientific article
English

Bioerodible injectable poly(ortho ester) for tetracycline controlled delivery to periodontal pockets: Preliminary trial in humans

Contributors

Schwach, Khadija; Loup, Pierre Jean; Vivien-Castioni, Nathalie; Mombelli, Andrea; Baehni, Pierre; Barr, J.; Heller, J.; Gurny, Robert

Published in

AAPS PharmSci, vol. 4, no. 4, p. 14-20

Publication date

2002

Abstract

The semisolid consistency of poly(ortho esters) (POEs) containing tetracycline free base allows direct injection in the periodontal pocket and shows sustained and almost constant in vitro release in phosphate buffer, pH 7.4 at 37°C, for up to 14 days. Total polymer degradation concomitant with drug release was obtained. Formulations containing 10% or 20% (wt/wt) tetracycline were evaluated in a panel of 12 patients suffering from severe and recurrent periodontitis. In the first trial including 6 patients, single-rooted teeth and molar teeth with furcations were treated immediately after scaling and root planing. Patients tolerated both formulations well, experienced no pain during application, and showed no signs of irritation or discomfort during the observation period. However, retention of the formulation was minimal in this first study. An improved clinical protocol followed in the second study (stopping bleeding after scaling and root planning) prolonged the retention of the formulations in the inflamed periodontal pockets. For up to 11 days, tetracycline concentrations in the gingival crevicular fluid were higher than the minimum inhibitory concentration of tetracycline against most periodontal pathogens.

Keywords

  • Periodontitis
  • Poly(ortho esters)
  • Bicerodible polymers
  • Tetracycline
  • Controlled release
  • Sustained delivery system

UNIGE affiliation entities

Citation (ISO format)

SCHWACH, Khadija et al. Bioerodible injectable poly(ortho ester) for tetracycline controlled delivery to periodontal pockets: Preliminary trial in humans. In: AAPS PharmSci, 2002, vol. 4, n° 4, p. 14–20. doi: 10.1208/ps040420

Main files (1)

Article (Published version)

Identifiers

Additional URL for this publication

http://www.springerlink.com/index/10.1208/ps040420

Journal ISSN

1522-1059
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Technical informations

Creation

11/01/2016 08:15:00

First validation

11/01/2016 08:15:00

Update

15/03/2023 00:02:27

Status update

15/03/2023 00:02:26

Last indexation

31/10/2024 02:27:22
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