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Title

Bioerodible injectable poly(ortho ester) for tetracycline controlled delivery to periodontal pockets: Preliminary trial in humans
Authors
Schwach, Khadija
Loup, Pierre Jean
Vivien-Castioni, Nathalie
Mombelli, Andrea
Baehni, Pierre
Barr, J.
Heller, J.
Gurny, Robert
Published in AAPS PharmSci. 2002, vol. 4, no. 4, p. 14-20
Abstract The semisolid consistency of poly(ortho esters) (POEs) containing tetracycline free base allows direct injection in the periodontal pocket and shows sustained and almost constant in vitro release in phosphate buffer, pH 7.4 at 37°C, for up to 14 days. Total polymer degradation concomitant with drug release was obtained. Formulations containing 10% or 20% (wt/wt) tetracycline were evaluated in a panel of 12 patients suffering from severe and recurrent periodontitis. In the first trial including 6 patients, single-rooted teeth and molar teeth with furcations were treated immediately after scaling and root planing. Patients tolerated both formulations well, experienced no pain during application, and showed no signs of irritation or discomfort during the observation period. However, retention of the formulation was minimal in this first study. An improved clinical protocol followed in the second study (stopping bleeding after scaling and root planning) prolonged the retention of the formulations in the inflamed periodontal pockets. For up to 11 days, tetracycline concentrations in the gingival crevicular fluid were higher than the minimum inhibitory concentration of tetracycline against most periodontal pathogens.
Keywords Periodontitis — Poly(ortho esters) — Bicerodible polymers — Tetracycline — Controlled release — Sustained delivery system
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Full text
Article (Published version) (466 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.springerlink.com/index/10.1208/ps040420
Structures
Faculté des sciences / Section des sciences pharmaceutiques
Faculté de médecine / Section de médecine dentaire / Division de physio-pathologie buccale et parodontie
Citation
(ISO format) 		SCHWACH, Khadija et al. Bioerodible injectable poly(ortho ester) for tetracycline controlled delivery to periodontal pockets: Preliminary trial in humans. In: AAPS PharmSci, 2002, vol. 4, n° 4, p. 14-20. https://archive-ouverte.unige.ch/unige:79137

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Deposited on : 2016-01-12

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