UNIGE document Scientific Article
previous document  unige:79118  next document
add to browser collection
Title

A systems proteomics view of the endogenous human claudin protein family

Authors
Liu, Fei
Koval, Michael
Ranganathan, Shoba
Fanayan, Susan
Hancock, William S
Lundberg, Emma K
Beavis, Ronald C
show hidden authors show all authors [1 - 12]
Published in Journal of Proteome Research. 2015
Abstract Claudins are the major transmembrane protein components of tight junctions in human endothelia and epithelia. Tissue-specific expression of claudin members suggests that this protein family is not only essential for sustaining the role of tight junction in cell permeability control but also vital in organizing cell contact signaling by protein-protein interactions. How this family of protein is collectively processed and regulated is key to understanding the role of junctional proteins in preserving cell identity and tissue integrity. The focus of this review is to first provide a brief overview of the functional context, on the basis of the extensive body of claudin biology research that has been thoroughly reviewed, for endogenous human claudin members and then ascertain existing and future proteomics techniques that may be applicable to systematically characterizing the chemical forms and interacting protein partners of this protein family in human. The ability to elucidate claudin-based signaling networks may provide new insight into cell development and differentiation programs that are crucial to tissue stability and manipulation.
Identifiers
PMID: 26680015
Full text
Article (Author postprint) (1.6 MB) - public document Free access
Structures
Research groups Calipho (80)
Swiss Institute of Bioinformatics
Citation
(ISO format)
LIU, Fei et al. A systems proteomics view of the endogenous human claudin protein family. In: Journal of Proteome Research, 2015. https://archive-ouverte.unige.ch/unige:79118

119 hits

37 downloads

Update

Deposited on : 2016-01-12

Export document
Format :
Citation style :