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Scientific article
English

Enantiomeric separation of cyclopropane derivatives on a polysaccharide-based chiral stationary phase

Published inAnalytica chimica acta, vol. 538, no. 1-2, p. 15-24
Publication date2005
Abstract

The enantioseparation of a set of new cyclopropanes derived from Meldrum's acid, dimethyl malonate, (silanoxyvinyl)-diazoacetates and 3,3,3-trifluoro-2-diazopropionate has been achieved on cellulose tris(3,5-dimethylphenylcarbamate) Chiralcel OD coated on 10 µm silica-gel as chiral stationary phase in high-performance liquid chromatography (HPLC). The HPLC was equipped with a sensitive optical rotation detector for monitoring the optical activity of the racemic and enantioenriched cyclopropanes prepared via the Rh(II)-catalyzed asymmetric intermolecular cyclopropanations. The mobile phase was a mixture of n-hexane-2-propanol (90:10, or 99:1, v/v) with a flow-rate of 0.3 ml/min. The UV detector was set at 254 nm. The advantages of the liquid over the gas chromatographic analysis of the cyclopropanes are demonstrated by a comparative study of both methods. The methods provide an easy and direct determination of the enantiomeric excesses of the cyclopropanes.

Keywords
  • Cellulose tris(3,5-dimethylphenylcarbamate)
  • Cyclopropanes
  • Enantiomeric excess
  • Enantioseparation
  • HPLC
  • Polysaccharide chiral stationary phase
  • Rhodium complexes
Citation (ISO format)
GHANEM ABDALLAH, Ashraf et al. Enantiomeric separation of cyclopropane derivatives on a polysaccharide-based chiral stationary phase. In: Analytica chimica acta, 2005, vol. 538, n° 1-2, p. 15–24. doi: 10.1016/j.aca.2005.02.038
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