Rigid-Rod Molecules in Biomembrane Models: From Hydrogen-Bonded Chains to Synthetic Multifunctional Pores

Sakai, Naomi; Mareda, Jiri; Matile, Stefan

doi:10.1021/ar0400802

Scientific article

English

Rigid-Rod Molecules in Biomembrane Models: From Hydrogen-Bonded Chains to Synthetic Multifunctional Pores

Contributors

Sakai, Naomi

; Mareda, Jiri; Matile, Stefan

Published in

Accounts of chemical research, vol. 38, no. 2, p. 79-87

Publication date

2005

Abstract

Synthetic ion channels and pores formed by rigid-rod molecules are summarized. This includes work on hydrogen-bonded chains installed along membrane-spanning rigid-rod scaffolds to transport protons. As a second topic, programmed assembly of p-septiphenyls with terminal iminodiacetate-copper complexes for potassium transport by cation-p interactions is described. The third topic concerns rigid push-pull rods as fluorescent a-helix mimics to probe the importance of dipole-potential interactions for voltage gating, both on the functional and the structural level. Topic number four deals with p-octiphenyl staves as key scaffolds for the synthesis of rigid-rod ß-barrel pores. The description of internal and external design strategies for these rigid-rod ß-barrels covers a rich collection of pH-, pM-, voltage-, ligand-, and enzyme-gated synthetic multifunctional pores that can act as hosts, sensors, and catalysts. As far as practical applications are concerned, the possibility to detect chemical reactions with synthetic multifunctional pores appears most attractive. Recent molecular mechanics simulations are presented as a valuable approach to insights on the elusive suprastructures of multifunctional pores made from rigid rods.

UNIGE affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

SAKAI, Naomi, MAREDA, Jiri, MATILE, Stefan. Rigid-Rod Molecules in Biomembrane Models: From Hydrogen-Bonded Chains to Synthetic Multifunctional Pores. In: Accounts of chemical research, 2005, vol. 38, n° 2, p. 79–87. doi: 10.1021/ar0400802

Article

Identifiers

PID : unige:7905
DOI : 10.1021/ar0400802
PMID : 15709727

Journal ISSN

0001-4842

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Rigid-Rod Molecules in Biomembrane Models: From Hydrogen-Bonded Chains to Synthetic Multifunctional Pores

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Published in

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Abstract

UNIGE affiliation entities

Citation (ISO format)

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Creation

First validation

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Status update

Last indexation