UNIGE document Scientific Article
previous document  unige:7900  next document
add to browser collection
Title

Direct Observation of Anion-Mediated Translocation of Fluorescent Oligoarginine Carriers into and across Bulk Liquid and Anionic Bilayer Membranes

Authors
Futaki, Shiroh
Published in ChemBioChem. 2005, vol. 6, no. 1, p. 114-122
Abstract The recent hypothesis that counteranion-mediated dynamic inversion of charge and solubility might contribute to diverse functions of oligoarginines in biomembranes was tested with two fluorescently labelled oligomers, FL-R8, one of the most active cell-penetrating peptides, and its longer version, FL-R16. We report evidence for counteranion-mediated phase transfer from water into bulk chloroform and anionic lipid-bilayer membranes as well as reverse-phase transfer from bulk chloroform and across intact lipid-bilayer membranes into water. The differences found between FL-R8 and FL-R16 with regard to location in the bilayer and reverse-phase transfer from bulk and lipid-bilayer membranes into water implied that the reported results may be relevant for biological function.
Keywords AnionsBioorganic chemistryIon pairsLipid bilayersOligoarginines
Identifiers
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Structures
Citation
(ISO format)
SAKAI, Naomi et al. Direct Observation of Anion-Mediated Translocation of Fluorescent Oligoarginine Carriers into and across Bulk Liquid and Anionic Bilayer Membranes. In: ChemBioChem, 2005, vol. 6, n° 1, p. 114-122. https://archive-ouverte.unige.ch/unige:7900

124 hits

0 download

Update

Deposited on : 2010-06-21

Export document
Format :
Citation style :