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Binding of Organic Anions by Synthetic Supramolecular Metallopores with Internal Mg2+-Aspartate Complexes

Authors
Onouchi, Hisanari
Yashima, Eiji
Published in ChemBioChem. 2002, vol. 3, no. 11, p. 1089-1096
Abstract We report that cation-selective transmembrane pores formed by synthetic p-octiphenyl ß barrels with internal aspartate residues can be transformed into anion-permeable metallopores with internal Mg2+-aspartate complexes. These metallopores are shown to be useful for fluorimetric sensing of a broad variety of organic anions of biological relevance such as phytate, heparin, thiamine phosphates, and adenosine triphosphate. The negligible flippase activity measurable for Mg2+-free pores indicates that transmembrane p-octiphenyl barrels do not disturb the lipid bilayer suprastructure, in other words, they form barrel-stave rather than toroidal pores.
Keywords Bioorganic chemistryFluorescenceLipid bilayersMolecular recognitionOligomers
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DAS, Gopal et al. Binding of Organic Anions by Synthetic Supramolecular Metallopores with Internal Mg2+-Aspartate Complexes. In: ChemBioChem, 2002, vol. 3, n° 11, p. 1089-1096. https://archive-ouverte.unige.ch/unige:7899

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Deposited on : 2010-06-21

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