Main aim of the present work is to underline the importance of local equipments management by advanced control systems and techniques for energy saving strategies in building sectors and especially in public buildings. In the framework of a relevant research about the evaluation of the energy and environmental performances of building stock in the Campus Leonardo-Bassini-Bonardi of Politecnico di Milano, an experimental diagnosis has been carried out. Due to the detailed diagnosis on the sample building it has been possible to evaluate the different conditions of usage and management of working spaces ad also main environmental parameters of thermal and visual comfort (temperature, solar radiation, lamps-on, electricity consumption and luminance). In fact, several times people unintentionally over-use the energy supplies and the effects are often significant in terms of energy wastes. The amount of energy wastes are related, on one hand, to the absence of any equipment dedicated to perform specific controls. In addition, also results from scientific literature in the field of energy savings due to control systems have been taken into account in the definition of energy benefits due to application of control strategies in Campus Leonardo-Bassini-Bonardi. At the end, several scenarios of intervention have been extended to the other buildings of the Campus. Final results could represent a benchmark to estimate the potential of improvement both for existing and for new similar buildings, in Italy and abroad.