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Spectroscopic Studies of PhTX-Facilitated Cation Movement Across Membranes

Huang, Xuefei
Borhan, Babak
Nakanishi, Koji
Published in Bioorganic & medicinal chemistry. 1999, vol. 7, no. 5, p. 811-814
Abstract Philanthotoxins, noncompetitive inhibitors of the nicotinic acetylcholine receptor and various glutamate receptors, were found to be capable of mediating cation transport across lipid bilayers. With respect to the relatively weak binding constants of these amphiphilic polyamines to neuronal receptor proteins, this finding implies that their interaction with cell membranes might have to be considered in addition to that with protein receptors to fully understand the molecular mechanism of these neurotoxins.
Keywords Philanthotoxinion carrier2Na NMRfluorescence
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HUANG, Xuefei et al. Spectroscopic Studies of PhTX-Facilitated Cation Movement Across Membranes. In: Bioorganic & medicinal chemistry, 1999, vol. 7, n° 5, p. 811-814. doi: 10.1016/S0968-0896(98)00257-0

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Deposited on : 2010-06-21

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