UNIGE document Scientific Article
previous document  unige:78862  next document
add to browser collection

Molecular imaging of matrix metalloproteinases in atherosclerotic plaques

Chaurand, Pierre
Published in Thrombosis and Haemostasis. 2012, vol. 107, no. 3, p. 409-416
Abstract Ischaemic stroke and myocardial infarction often result from the sudden rupture of an atherosclerotic plaque. The subsequent arterial thrombosis occluding the vessel lumen has been widely indicated as the crucial acute event causing peripheral tissue ischaemia. A complex cross-talk between systemic and intraplaque inflammatory mediators has been shown to regulate maturation, remodeling and final rupture of an atherosclerotic plaque. Matrix metalloproteinases (MMPs) are proteolytic enzymes (released by several cell subsets within atherosclerotic plaques), which favour atherogenesis and increase plaque vulnerability. Thus, the assessment of intraplaque levels and activity of MMP might be of pivotal relevance in the evaluation of the risk of rupture. New imaging approaches, focused on the visualisation of inflammation in the vessel wall and plaque, may emerge as tools for individualised risk assessment and prevention of events. In this review, we summarize experimental findings of the currently available invasive and noninvasive imaging techniques, used to detect the presence and activity of MMPs in atherosclerotic plaques.
Keywords Aneurysm, Ruptured/diagnosis/etiology/physiopathology/prevention & controlAtherosclerosis/complications/diagnosis/drug therapy/physiopathologyEnzyme ActivationHumansMatrix Metalloproteinases/metabolismMolecular ImagingPlaque, Atherosclerotic/enzymologyRisk Assessment
PMID: 22274652
Full text
Article (Published version) (105 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research group L'athérosclérose et ses complications cliniques (591)
(ISO format)
LENGLET, Sébastien et al. Molecular imaging of matrix metalloproteinases in atherosclerotic plaques. In: Thrombosis and Haemostasis, 2012, vol. 107, n° 3, p. 409-416. https://archive-ouverte.unige.ch/unige:78862

50 hits

0 download


Deposited on : 2015-12-21

Export document
Format :
Citation style :