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Title

The evolutionary patterns of hepatitis C virus subtype 2a and 6a isolates linked to an outbreak in China in 2012

Authors
Lu, Ling
An, Yuling
Zou, Ji
Gu, Lin
Zhao, Zhixin
Zhang, Xiaohong
Li, Chunhua
Kurihara, Chie
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Published in Virology. 2015, vol. 485, p. 431-438
Abstract An HCV outbreak occurred in 2012 in China, affecting hundreds of patients. We characterized HCV subtype 2a and 6a sequences from 60 and 102 patients, respectively, and co-analyzed them with 82 local controls and 103 calibrating references. The close grouping of the patients׳ sequences contrasted sharply with the diversity of local controls. Scaled by the calibrating references, the emergence of patients׳ isolates was estimated at 2-5 years before sampling. In contrast, the controls intermingled with the calibrating references that were much older. For both subtypes, the major and minor clusters could be defined, with the closeness to indicate linked transmission.
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PMID: 26343863
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Research group Etudes et traitement de l'hépatite C et B (554)
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LU, Ling et al. The evolutionary patterns of hepatitis C virus subtype 2a and 6a isolates linked to an outbreak in China in 2012. In: Virology, 2015, vol. 485, p. 431-438. https://archive-ouverte.unige.ch/unige:78849

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Deposited on : 2015-12-21

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