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Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus

Jallouli, M
Galicier, L
Zahr, N
Aumaître, O
Francès, C
Le Guern, V
Lioté, F
Smail, A
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Published in Arthritis and Rheumatology. 2015, vol. 67, no. 8, p. 2176-2184
Abstract Blood concentrations of hydroxychloroquine (HCQ) vary widely among patients with systemic lupus erythematosus (SLE). A pharmacokinetic/pharmacodynamic relationship has been found in different situations, and a very low blood concentration of HCQ is a simple marker of nonadherence to treatment. Therefore, interest in blood HCQ concentration measurement has increased, but little is known about factors that influence blood HCQ concentration variability. This study was undertaken to analyze determinants of blood HCQ concentrations.
Keywords Adrenal Cortex Hormones/therapeutic useAdultAntirheumatic Agents/blood/pharmacokinetics/therapeutic useBody Mass IndexCreatinine/bloodFemaleHumansHydroxychloroquine/blood/pharmacokinetics/therapeutic useLeukocyte CountLupus Erythematosus, Systemic/blood/complications/drug therapyMaleMiddle AgedMultivariate AnalysisNeutrophils/cytologyObesity/complicationsRenal Insufficiency, Chronic/complicationsRetrospective StudiesThrombocytopeniaTime FactorsYoung Adult
PMID: 25989906
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Research group Groupe Perrier Arnaud (Médecine interne générale, de réhabilitation et de gériatrie) (585)
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JALLOULI, M et al. Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus. In: Arthritis and Rheumatology, 2015, vol. 67, n° 8, p. 2176-2184. doi: 10.1002/art.39194 https://archive-ouverte.unige.ch/unige:78676

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Deposited on : 2015-12-16

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