en
Scientific article
English

Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus

Published inArthritis & rheumatology, vol. 67, no. 8, p. 2176-2184
Publication date2015
Abstract

Blood concentrations of hydroxychloroquine (HCQ) vary widely among patients with systemic lupus erythematosus (SLE). A pharmacokinetic/pharmacodynamic relationship has been found in different situations, and a very low blood concentration of HCQ is a simple marker of nonadherence to treatment. Therefore, interest in blood HCQ concentration measurement has increased, but little is known about factors that influence blood HCQ concentration variability. This study was undertaken to analyze determinants of blood HCQ concentrations.

Keywords
  • Adrenal Cortex Hormones/therapeutic use
  • Adult
  • Antirheumatic Agents/blood/pharmacokinetics/therapeutic use
  • Body Mass Index
  • Creatinine/blood
  • Female
  • Humans
  • Hydroxychloroquine/blood/pharmacokinetics/therapeutic use
  • Leukocyte Count
  • Lupus Erythematosus, Systemic/blood/complications/drug therapy
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neutrophils/cytology
  • Obesity/complications
  • Renal Insufficiency, Chronic/complications
  • Retrospective Studies
  • Thrombocytopenia
  • Time Factors
  • Young Adult
Citation (ISO format)
JALLOULI, M et al. Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus. In: Arthritis & rheumatology, 2015, vol. 67, n° 8, p. 2176–2184. doi: 10.1002/art.39194
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Article (Published version)
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Identifiers
ISSN of the journal2326-5191
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Technical informations

Creation11/07/2015 1:28:00 PM
First validation11/07/2015 1:28:00 PM
Update time03/14/2023 11:59:00 PM
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