Scientific article
English

Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus

Published inArthritis & rheumatology, vol. 67, no. 8, p. 2176-2184
Publication date2015
Abstract

Blood concentrations of hydroxychloroquine (HCQ) vary widely among patients with systemic lupus erythematosus (SLE). A pharmacokinetic/pharmacodynamic relationship has been found in different situations, and a very low blood concentration of HCQ is a simple marker of nonadherence to treatment. Therefore, interest in blood HCQ concentration measurement has increased, but little is known about factors that influence blood HCQ concentration variability. This study was undertaken to analyze determinants of blood HCQ concentrations.

Keywords
  • Adrenal Cortex Hormones/therapeutic use
  • Adult
  • Antirheumatic Agents/blood/pharmacokinetics/therapeutic use
  • Body Mass Index
  • Creatinine/blood
  • Female
  • Humans
  • Hydroxychloroquine/blood/pharmacokinetics/therapeutic use
  • Leukocyte Count
  • Lupus Erythematosus, Systemic/blood/complications/drug therapy
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neutrophils/cytology
  • Obesity/complications
  • Renal Insufficiency, Chronic/complications
  • Retrospective Studies
  • Thrombocytopenia
  • Time Factors
  • Young Adult
Citation (ISO format)
JALLOULI, M et al. Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus. In: Arthritis & rheumatology, 2015, vol. 67, n° 8, p. 2176–2184. doi: 10.1002/art.39194
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN2326-5191
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Technical informations

Creation07/11/2015 13:28:00
First validation07/11/2015 13:28:00
Update time14/03/2023 23:59:00
Status update14/03/2023 23:58:58
Last indexation31/10/2024 02:18:46
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