Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions

Bongoni, Anjan K; Kiermeir, David; Schnider, Jonas; Jenni, Hansjörg; Garimella, Pavan; Bähr, Andrea; Klymiuk, Nikolai; Wolf, Eckhard; Ayares, David; Voegelin, Esther; Constantinescu, Mihai A; Seebach, Jorg Dieter; Rieben, Robert

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Title		Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions
Authors		Bongoni, Anjan K Kiermeir, David Schnider, Jonas Jenni, Hansjörg Garimella, Pavan Bähr, Andrea Klymiuk, Nikolai Wolf, Eckhard Ayares, David Voegelin, Esther Constantinescu, Mihai A Seebach, Jorg Dieter Rieben, Robert show all authors [1 - 13]
Published in		Transplantation. 2015, vol. 99, no. 10, p. 2061-2069
Abstract		Dysregulation of the coagulation system due to inflammatory responses and cross-species molecular incompatibilities represents a major obstacle to successful xenotransplantation. We hypothesized that complement inhibition mediated by transgenic expression of human CD46 in pigs might also regulate the coagulation and fibrinolysis cascades and tested this in ex vivo human-to-pig xenoperfusions.
Identifiers		DOI: 10.1097/TP.0000000000000746 PMID: 25965410
Full text		Article (Published version) (1.9 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Research group		Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
Citation (ISO format)		BONGONI, Anjan K et al. Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions. In: Transplantation, 2015, vol. 99, n° 10, p. 2061-2069. https://archive-ouverte.unige.ch/unige:78625