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Title

Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions

Authors
Bongoni, Anjan K
Kiermeir, David
Schnider, Jonas
Jenni, Hansjörg
Garimella, Pavan
Bähr, Andrea
Klymiuk, Nikolai
Wolf, Eckhard
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Published in Transplantation. 2015, vol. 99, no. 10, p. 2061-2069
Abstract Dysregulation of the coagulation system due to inflammatory responses and cross-species molecular incompatibilities represents a major obstacle to successful xenotransplantation. We hypothesized that complement inhibition mediated by transgenic expression of human CD46 in pigs might also regulate the coagulation and fibrinolysis cascades and tested this in ex vivo human-to-pig xenoperfusions.
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PMID: 25965410
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Research group Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
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BONGONI, Anjan K et al. Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions. In: Transplantation, 2015, vol. 99, n° 10, p. 2061-2069. https://archive-ouverte.unige.ch/unige:78625

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Deposited on : 2015-12-14

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