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Title

Porcine extrahepatic vascular endothelial asialoglycoprotein receptor 1 mediates xenogeneic platelet phagocytosis in vitro and in human-to-pig ex vivo xenoperfusion

Authors
Bongoni, Anjan K
Kiermeir, David
Denoyelle, Julie
Jenni, Hansjörg
Burlak, Christopher
Vögelin, Esther
Constantinescu, Mihai A
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Published in Transplantation. 2015, vol. 99, no. 4, p. 693-701
Abstract Asialoglycoprotein receptor-1 (ASGR1) mediates capture and phagocytosis of platelets in pig-to-primate liver xenotransplantation. However, thrombocytopenia is also observed in xenotransplantation or xenoperfusion of other porcine organs than liver. We therefore assessed ASGR1 expression as well as ASGR1-mediated xenogeneic platelet phagocytosis in vitro and ex vivo on porcine aortic, femoral arterial, and liver sinusoidal endothelial cells (PAEC/PFAEC/PLSEC).
Keywords AmputationAnimalsAsialoglycoprotein Receptor/immunology/metabolismBlood Platelets/immunology/metabolismBlood Transfusion/methodsCells, CulturedEndothelial Cells/immunology/metabolismFemaleForelimb/blood supply/surgeryHumansMaleModels, AnimalPhagocytosisPlatelet AdhesivenessSignal TransductionSpecies SpecificitySwineThrombocytopenia/blood/immunologyTime FactorsTransplantation, Heterologous
Identifiers
PMID: 25675194
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Research group Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
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BONGONI, Anjan K et al. Porcine extrahepatic vascular endothelial asialoglycoprotein receptor 1 mediates xenogeneic platelet phagocytosis in vitro and in human-to-pig ex vivo xenoperfusion. In: Transplantation, 2015, vol. 99, n° 4, p. 693-701. https://archive-ouverte.unige.ch/unige:78624

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Deposited on : 2015-12-14

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