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Title

Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors

Authors
Kroy, Daniela C
Cooperrider, Jennifer H
Tomlinson, Michelle
Hauck, Garrett D
Aneja, Jasneet
Wolski, David
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Published in Gastroenterology. 2014, vol. 146, no. 2, p. 550-561
Abstract There is an unclear relationship between inhibitory receptor expression on T cells and their ability to control viral infections. Studies of human immune cells have been mostly limited to T cells from blood, which is often not the site of infection. We investigated the relationship between T-cell location, expression of inhibitory receptors, maturation, and viral control using blood and liver T cells from patients with hepatitis C virus (HCV) and other viral infections.
Keywords Antigens, CD/metabolismBiological Markers/metabolismCD4-Positive T-Lymphocytes/metabolismCD8-Positive T-Lymphocytes/metabolismCase-Control StudiesFemaleFlow CytometryHepacivirus/physiologyHepatitis C, Chronic/blood/immunology/virologyHumansLiver/immunology/virologyMaleMembrane Proteins/metabolismMiddle AgedPhenotypeProgrammed Cell Death 1 Receptor/metabolismReceptors, Immunologic/metabolismVirus Replication
Identifiers
PMID: 24148617
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KROY, Daniela C et al. Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. In: Gastroenterology, 2014, vol. 146, n° 2, p. 550-561. https://archive-ouverte.unige.ch/unige:78622

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Deposited on : 2015-12-14

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