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Scientific article
English

Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors

Published inGastroenterology, vol. 146, no. 2, p. 550-561
Publication date2014
Abstract

There is an unclear relationship between inhibitory receptor expression on T cells and their ability to control viral infections. Studies of human immune cells have been mostly limited to T cells from blood, which is often not the site of infection. We investigated the relationship between T-cell location, expression of inhibitory receptors, maturation, and viral control using blood and liver T cells from patients with hepatitis C virus (HCV) and other viral infections.

Keywords
  • Antigens, CD/metabolism
  • Biological Markers/metabolism
  • CD4-Positive T-Lymphocytes/metabolism
  • CD8-Positive T-Lymphocytes/metabolism
  • Case-Control Studies
  • Female
  • Flow Cytometry
  • Hepacivirus/physiology
  • Hepatitis C, Chronic/blood/immunology/virology
  • Humans
  • Liver/immunology/virology
  • Male
  • Membrane Proteins/metabolism
  • Middle Aged
  • Phenotype
  • Programmed Cell Death 1 Receptor/metabolism
  • Receptors, Immunologic/metabolism
  • Virus Replication
Affiliation Not a UNIGE publication
Citation (ISO format)
KROY, Daniela C et al. Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. In: Gastroenterology, 2014, vol. 146, n° 2, p. 550–561. doi: 10.1053/j.gastro.2013.10.022
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0016-5085
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