en
Scientific article
English

Late antibody-mediated rejection by de novo donor HLA-DP-specific antibody after renal transplantation: a case report

Published inHuman immunology, vol. 75, no. 5, p. 462-465
Publication date2014
Abstract

The role of donor HLA-DP-specific antibodies after renal transplantation is controversial, and only preformed HLA-DP-specific antibodies have been shown to mediate rejection. Here we present a case of late humoral rejection mediated by de novo donor HLA-DP-specific antibodies in a non-sensitized recipient. This unique case demonstrates the pathogenic role of de novo anti-DP antibodies and suggests that HLA-DP matching might be relevant for renal transplantation.

Keywords
  • Antibodies/blood/immunology
  • Antibody-Dependent Cell Cytotoxicity/immunology
  • Biopsy
  • Graft Rejection/immunology
  • HLA-DP Antigens/immunology
  • Humans
  • Kidney Failure, Chronic/complications/immunology/pathology/therapy
  • Kidney Glomerulus/pathology
  • Kidney Transplantation/adverse effects
  • Male
  • Middle Aged
Citation (ISO format)
CIPPÀ, Pietro E et al. Late antibody-mediated rejection by de novo donor HLA-DP-specific antibody after renal transplantation: a case report. In: Human immunology, 2014, vol. 75, n° 5, p. 462–465. doi: 10.1016/j.humimm.2014.02.008
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0198-8859
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