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Title

Late antibody-mediated rejection by de novo donor HLA-DP-specific antibody after renal transplantation: a case report

Authors
Cippà, Pietro E
Gaspert, Ariana
Etter, Christoph
Guenduez, Zehra
Rüsi, Barbara
Fehr, Thomas
Published in Human Immunology. 2014, vol. 75, no. 5, p. 462-465
Abstract The role of donor HLA-DP-specific antibodies after renal transplantation is controversial, and only preformed HLA-DP-specific antibodies have been shown to mediate rejection. Here we present a case of late humoral rejection mediated by de novo donor HLA-DP-specific antibodies in a non-sensitized recipient. This unique case demonstrates the pathogenic role of de novo anti-DP antibodies and suggests that HLA-DP matching might be relevant for renal transplantation.
Keywords Antibodies/blood/immunologyAntibody-Dependent Cell Cytotoxicity/immunologyBiopsyGraft Rejection/immunologyHLA-DP Antigens/immunologyHumansKidney Failure, Chronic/complications/immunology/pathology/therapyKidney Glomerulus/pathologyKidney Transplantation/adverse effectsMaleMiddle Aged
Identifiers
PMID: 24530822
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Structures
Research group Transplantation Immunologie et Osteoimmunologie (561)
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CIPPÀ, Pietro E et al. Late antibody-mediated rejection by de novo donor HLA-DP-specific antibody after renal transplantation: a case report. In: Human Immunology, 2014, vol. 75, n° 5, p. 462-465. https://archive-ouverte.unige.ch/unige:78620

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Deposited on : 2015-12-14

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