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Title

The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis: a potential target for treating thrombotic diseases

Authors
Fraga-Silva, Rodrigo A
Da Silva, Danielle G
Stergiopulos, Nikolaos
da Silva, Rafaela F
Santos, Robson A S
Published in Thrombosis and Haemostasis. 2012, vol. 108, no. 6, p. 1089-1096
Abstract Despite many therapeutic advances leading to increasingly effective drug treatments, thrombotic events (such as ischaemic stroke, pulmonary embolism, deep venous thrombosis and acute myocardial infarction) still represent a major worldwide cause of morbidity and mortality. Remarkable effort has been made to identify new drug targets. There is growing evidence indicating that the recently described counter-regulator axis of the renin-angiotensin system (RAS), composed of Angiotensin-Converting Enzyme 2 (ACE2), Angiotensin-(1-7) and the Mas receptor, has protective effects against thrombosis. In addition, it could be considered as a promising target for treating or preventing this disease. In this narrative review, we focused on the recent findings of the role of the ACE2/Angiotensin-(1-7)/Mas axis on the haemostatic process and its therapeutic potential.
Keywords Angiotensin II Type 1 Receptor Blockers/pharmacologyAngiotensin-Converting Enzyme Inhibitors/pharmacologyHemostasis/drug effects/physiologyHumansModels, CardiovascularPeptidyl-Dipeptidase A/physiologyProto-Oncogene Proteins/physiologyReceptor, Angiotensin, Type 1/physiologyReceptors, G-Protein-Coupled/physiologyRenin-Angiotensin System/drug effects/physiologyThrombosis/blood/drug therapy/physiopathology
Identifiers
PMID: 23093373
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Article (Published version) (207 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group L'athérosclérose et ses complications cliniques (591)
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(ISO format)
FRAGA-SILVA, Rodrigo A et al. The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis: a potential target for treating thrombotic diseases. In: Thrombosis and Haemostasis, 2012, vol. 108, n° 6, p. 1089-1096. https://archive-ouverte.unige.ch/unige:78604

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Deposited on : 2015-12-14

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