UNIGE document Scientific Article
previous document  unige:786  next document
add to browser collection
Title

Microbubble potentiated transcranial duplex ultrasound enhances IV thrombolysis in acute stroke

Authors
Loulidi, Jaouad
Poglia, Davide
Published in Journal of Thrombosis and Thrombolysis. 2008, vol. 25, no. 2, p. 219-23
Abstract BACKGROUND: We studied whether 2 MHz transcranial color-coded duplex ultrasound (TCCD), combined with a second generation ECA, accelerate IV rtPA-thrombolysis in the acute phase of MCA stroke more than TCCD monitoring alone. METHODS: Non-randomized acute MCA stroke patients undergoing IV rtPA-thrombolysis and 2 MHZ-TCCD monitoring over 60 min, with (N = 11) or without (N = 15) additional continuous ECA (5 ml, SonoVue perfusion, were compared. Recanalization of the MCA was measured pre- and post-thrombolysis with the thrombolysis in brain ischemia (TIBI) grading system, clinical outcome was assessed at admission and 24 h after treatment using the NIH stroke scale (NIHSS). RESULTS: Patients who received ECA improved their NIHSS significantly more than those who were only TCCD monitored (Mann-Whitney U = 48.0; P = 0.050), and their flow signal improved more (Mann-Whitney U = 40.0; P < 0.03). CONCLUSIONS: The results of this pilot study show that in IV-thrombolysis the use of ECA in addition to TCCD monitoring lead to a greater immediate clinical improvement and to a better flow signal.
Keywords AgedFemaleHumansInfarction Middle Cerebral Artery/drug therapy/ultrasonographyMaleMicrobubblesPhospholipids/diagnostic use/therapeutic useSulfur Hexafluoride/diagnostic use/therapeutic useThrombolytic TherapyTissue Plasminogen Activator/therapeutic useUltrasonography Doppler Color
Identifiers
PMID: 17514430
Full text
Structures
Citation
(ISO format)
PERREN, Fabienne et al. Microbubble potentiated transcranial duplex ultrasound enhances IV thrombolysis in acute stroke. In: Journal of Thrombosis and Thrombolysis, 2008, vol. 25, n° 2, p. 219-23. https://archive-ouverte.unige.ch/unige:786

164 hits

0 download

Update

Deposited on : 2009-02-12

Export document
Format :
Citation style :