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Microbubble potentiated transcranial duplex ultrasound enhances IV thrombolysis in acute stroke

Loulidi, Jaouad
Poglia, Davide
Published in Journal of Thrombosis and Thrombolysis. 2008, vol. 25, no. 2, p. 219-23
Collection Open Access - Licence nationale Springer
Abstract BACKGROUND: We studied whether 2 MHz transcranial color-coded duplex ultrasound (TCCD), combined with a second generation ECA, accelerate IV rtPA-thrombolysis in the acute phase of MCA stroke more than TCCD monitoring alone. METHODS: Non-randomized acute MCA stroke patients undergoing IV rtPA-thrombolysis and 2 MHZ-TCCD monitoring over 60 min, with (N = 11) or without (N = 15) additional continuous ECA (5 ml, SonoVue perfusion, were compared. Recanalization of the MCA was measured pre- and post-thrombolysis with the thrombolysis in brain ischemia (TIBI) grading system, clinical outcome was assessed at admission and 24 h after treatment using the NIH stroke scale (NIHSS). RESULTS: Patients who received ECA improved their NIHSS significantly more than those who were only TCCD monitored (Mann-Whitney U = 48.0; P = 0.050), and their flow signal improved more (Mann-Whitney U = 40.0; P < 0.03). CONCLUSIONS: The results of this pilot study show that in IV-thrombolysis the use of ECA in addition to TCCD monitoring lead to a greater immediate clinical improvement and to a better flow signal.
Keywords AgedFemaleHumansInfarction Middle Cerebral Artery/drug therapy/ultrasonographyMaleMicrobubblesPhospholipids/diagnostic use/therapeutic useSulfur Hexafluoride/diagnostic use/therapeutic useThrombolytic TherapyTissue Plasminogen Activator/therapeutic useUltrasonography Doppler Color
PMID: 17514430
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PERREN, Fabienne et al. Microbubble potentiated transcranial duplex ultrasound enhances IV thrombolysis in acute stroke. In: Journal of Thrombosis and Thrombolysis, 2008, vol. 25, n° 2, p. 219-23. doi: 10.1007/s11239-007-0044-6 https://archive-ouverte.unige.ch/unige:786

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Deposited on : 2009-02-12

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