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Title

Update on the endocannabinoid-mediated regulation of gelatinase release in arterial wall physiology and atherosclerotic pathophysiology

Authors
Michel-Monigadon, Delphine
Steffens, Sabine
Published in Expert Review of Cardiovascular Therapy. 2012, vol. 10, no. 12, p. 1481-1486
Abstract Endocannabinoids are endogenous bioactive lipids ubiquitously distributed in several tissues (e.g., brain, adipose tissue, liver, heart and arterial vessels), which play a crucial role in atherosclerosis. Endocannabinoids have been shown to promote cell homeostasis and modulate inflammatory bioactivities mainly via the binding to transmembrane receptors (called cannabinoid type 1 and cannabinoid type 2 receptors, respectively). Although other cannabinoid receptors have been recently identified and shown to play a crucial role in cardiovascular pathophysiology, so far, the pharmacological targeting of both cannabinoid type 1 and cannabinoid type 2 receptors has been described as a promising therapeutic target in atherogenesis and associated inflammatory processes. In particular, endocannabinoids have been shown to modulate the release and activation of matrix degrading enzymes (i.e., matrix metalloproteinases [MMPs]) increasing intraplaque vulnerability. In this article the authors describe the pivotal regulatory activity of the endocannabinoid system on gelatinase (MMP-2 and -9) bioactivity in the arterial wall physiology and pathophysiology.
Keywords AnimalsArteries/metabolismAtherosclerosis/physiopathologyEndocannabinoids/physiologyGelatinases/metabolismHumansMatrix Metalloproteinases/physiologyNeovascularization, Physiologic/physiologyReceptors, Cannabinoid/physiology
Identifiers
PMID: 23253273
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Research group L'athérosclérose et ses complications cliniques (591)
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MICHEL-MONIGADON, Delphine et al. Update on the endocannabinoid-mediated regulation of gelatinase release in arterial wall physiology and atherosclerotic pathophysiology. In: Expert Review of Cardiovascular Therapy, 2012, vol. 10, n° 12, p. 1481-1486. https://archive-ouverte.unige.ch/unige:78595

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Deposited on : 2015-12-14

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