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Analysis and monitoring of anti-HLA antibodies in solid-organ and stem cell transplantation : What to do? When should they be tested?

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Defense Thèse de privat-docent : Univ. Genève, 2015
Abstract Due to the shortage of deceased donor the search for suitable kidney from living donors has intensified. Unfortunately, recipient-donor couples are often HLA-mismatched due to the high polymorphism of HLA loci. Nowadays patients often need more than one transplant during their lifetime and are at major risk factor for developing anti-HLA antibodies. To deal with this problem, we increased the number of tests and their sensitivity, and by carrying out accurate HLA-typing to ensure more appropriate organ allocation and the efficient follow-up and treatment of recipients. We increased our catalogue of assays and developed guidelines for physicians regarding the acceptance of organs and an adequate follow-up of their patients. With strategies such as living-donor, ABO-incompatible kidney transplantation and compatible non-directed donor exchange, we have so far obtained 100% graft survival for all types of living-donor kidney transplantation, as well as an excellent survival rate for pancreas and islet grafts.
Keywords TransplantationHLAAnticorpsAntiHLAAnalyses médicales
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FERRARI-LACRAZ, Sylvie. Analysis and monitoring of anti-HLA antibodies in solid-organ and stem cell transplantation : What to do? When should they be tested?. Université de Genève. Thèse de privat-docent, 2015. doi: 10.13097/archive-ouverte/unige:78536 https://archive-ouverte.unige.ch/unige:78536

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Deposited on : 2015-12-10

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