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Hippocampal sclerosis and chronic epilepsy following posterior reversible encephalopathy syndrome

Wohlrab, Gabriele
Published in Epileptic Disorders. 2013, vol. 15, no. 4, p. 451-454
Abstract Chronic epilepsy has rarely been reported after posterior reversible encephalopathy syndrome (PRES) and the association with hippocampal sclerosis has been suggested only once before. We report the case of a girl admitted at the age of 8 years with idiopathic nephrotic syndrome. On the second day of admission, she presented with focal complex seizures and cerebral MRI showed posterior encephalopathy and no hippocampal sclerosis. MRI after one month confirmed the diagnosis of PRES. The seizures recurred and the girl developed pharmacoresistant epilepsy and was admitted to our hospital for further investigation. Cerebral MRI three years after the diagnosis of PRES showed hippocampal sclerosis which was not present on the initial MRI. We conclude that there is a triggering role of PRES in the development of hippocampal sclerosis. Hippocampal sclerosis may have resulted from seizure-associated damage, alternatively, hypertensive encephalopathy may have led to hippocampal damage via a vascular mechanism.
Keywords ChildChronic DiseaseEpilepsy/complications/diagnosis/pathologyFemaleHippocampus/pathologyHumansHypertensive Encephalopathy/complications/diagnosis/etiology/pathologyMagnetic Resonance Imaging/methodsSclerosis/diagnosis/etiology
PMID: 24515311
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Research groups Epilepsie et Chirurgie (149)
Optimisations des techniques avancés en neuroimagerie (985)
Epilepsie et réseaux cérébraux (1002)
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KAPINA, Viktoria et al. Hippocampal sclerosis and chronic epilepsy following posterior reversible encephalopathy syndrome. In: Epileptic Disorders, 2013, vol. 15, n° 4, p. 451-454. doi: 10.1684/epd.2013.0617 https://archive-ouverte.unige.ch/unige:78143

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Deposited on : 2015-12-03

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