Modeling the Selectivity of Potassium Channels with Synthetic, Ligand-Assembled π-Slides

Tedesco, Maureen M.; Ghebremariam, Bereket; Sakai, Naomi; Matile, Stefan

doi:10.1002/(SICI)1521-3757(19990215)111:4<523::AID-ANGE523>3.0.CO;2-Q

Scientific article

English

Modeling the Selectivity of Potassium Channels with Synthetic, Ligand-Assembled π-Slides

ContributorsTedesco, Maureen M.; Ghebremariam, Bereket; Sakai, Naomi

; Matile, Stefan

Published inAngewandte Chemie, vol. 38, no. 4, p. 540-543

Publication date1999

Abstract

A supramolecular ion channel model mediates transmembrane ion transport (shown schematically) with a selectivity topology similar to that of K+ channels. This supports the biological significance of flexible arene arrays as selective cation binding sites.

Keywords

Ion channels
Ligand effects
Membranes
Protein mimetics
Supramolecular chemistry

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

TEDESCO, Maureen M. et al. Modeling the Selectivity of Potassium Channels with Synthetic, Ligand-Assembled π-Slides. In: Angewandte Chemie, 1999, vol. 38, n° 4, p. 540–543. doi: 10.1002/(SICI)1521-3757(19990215)111:4<523::AID-ANGE523>3.0.CO;2-Q

Article

Identifiers

PID : unige:7813
DOI : 10.1002/(SICI)1521-3757(19990215)111:4<523::AID-ANGE523>3.0.CO;2-Q

Journal ISSN1433-7851

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Modeling the Selectivity of Potassium Channels with Synthetic, Ligand-Assembled π-Slides

A supramolecular ion channel model mediates transmembrane ion transport (shown schematically) with a selectivity topology similar to that of K+ channels. This supports the biological significance of flexible arene arrays as selective cation binding sites.

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