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[What's new in internal medicine?]

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Published in Annales de dermatologie et de vénéréologie. 2014, vol. 141 Suppl 4, p. S616-S621
Abstract This article focuses on current trends in various autoimmune diseases of interest for the dermatologist. In the antiphospholipid syndrome, many news: better characterization of the severe disease, involvement of the mTOR pathway in the vasculopathy-induced renal disease, and diversification of the therapeutic approaches: use of mTOR inhibitors and several biologics, new various antiplatelet and anticoagulants. In dermatomyositis, new autoantibodies are better characterized with a good correlation with clinical disease; the results of a large study on genetic predisposition to the disease are available. There are also some therapeutic innovations in systemic sclerosis: benefit of rituximab that seems well tolerated, the results of a large controlled European study about aggressive immunoablative chemotherapy followed by autologous stem cells have just been published, intralesional stem cells injections in the fingers of sclerodactylic patients. Finally, news in celiac disease that is constantly increasing and whose mild forms often have cutaneous manifestations, leading to diagnosis.
Keywords Anticoagulants/therapeutic useAntiphospholipid Syndrome/complications/immunologyAntirheumatic Agents/therapeutic useAutoantibodies/immunologyAutoimmune Diseases/drug therapy/immunology/therapyBiological Products/therapeutic useCeliac Disease/genetics/immunologyCombined Modality TherapyGenetic Predisposition to DiseaseHematopoietic Stem Cell TransplantationHumansImmunosuppressive Agents/therapeutic useInternal Medicine/trendsScleroderma, Systemic/therapySkin Diseases/drug therapy/immunology/therapyThrombophilia/etiologyTransplantation, Autologous
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PMID: 25539753
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LAFFITTE, Emmanuel Alexis. [What's new in internal medicine?]. In: Annales de Dermatologie et de Venereologie, 2014, vol. 141 Suppl 4, p. S616-S621. doi: 10.1016/S0151-9638(14)70165-6 https://archive-ouverte.unige.ch/unige:78090

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Deposited on : 2015-12-02

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