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Title

Toxoplasma as a novel system for motility

Authors
Meissner, Markus
Published in Current Opinion in Cell Biology. 2004, vol. 16, no. 1, p. 32-40
Abstract Motility is a characteristic of most living organisms and often requires specialized structures like cilia or flagella. An alternative is amoeboid movement, where the polymerization/depolymerization of actin leads to the formation of pseudopodia, filopodia and/or lamellipodia that enable the cell to crawl along a surface. Despite their lack of locomotive organelles and in absence of cell deformation, members of the apicomplexan parasites employ a unique form of locomotion called gliding motility to promote their migration across biological barriers and to power host-cell invasion and egress. Detailed studies in Toxoplasma gondii and Plasmodium species have revealed that this unique mode of movement is dependent on a myosin of class XIV and necessitates actin dynamics and the concerted discharge and processing of adhesive proteins. Gliding is essential for the survival and infectivity of these obligate intracellular parasites, which cause severe disease in humans and animals.
Keywords Actins/metabolismAnimalsCytoskeleton/physiologyLocomotionModels, AnimalMyosins/geneticsPlasmodium falciparum/chemistry/physiologySignal TransductionToxoplasma/cytology/physiology
Identifiers
PMID: 15037302
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Article (Author postprint) (537 Kb) - public document Free access
Structures
Research group Biologie d'un parasite intracellulaire obligatoire (773)
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SOLDATI-FAVRE, Dominique, MEISSNER, Markus. Toxoplasma as a novel system for motility. In: Current Opinion in Cell Biology, 2004, vol. 16, n° 1, p. 32-40. https://archive-ouverte.unige.ch/unige:78036

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Deposited on : 2015-12-02

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