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The glideosome: a molecular machine powering motility and host-cell invasion by Apicomplexa

Keeley, Anthony
Published in Trends in Cell Biology. 2004, vol. 14, no. 10, p. 528-532
Abstract The apicomplexans are obligate intracellular protozoan parasites that rely on gliding motility for their migration across biological barriers and for host-cell invasion and egress. This unusual form of substrate-dependent motility is powered by the "glideosome", a macromolecular complex consisting of adhesive proteins that are released apically and translocated to the posterior pole of the parasite by the action of an actomyosin system anchored in the inner membrane complex of the parasite. Recent studies have revealed new insights into the composition and biogenesis of Toxoplasma gondii myosin-A motor complex and have identified an exciting set of small molecules that can interfere with different aspects of glideosome function.
Keywords AnimalsApicomplexa/cytology/physiologyCell Movement/physiologyHost-Parasite Interactions/physiologyHumansMolecular Motor Proteins/physiology
PMID: 15450974
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Article (Author postprint) (639 Kb) - public document Free access
Research group Biologie d'un parasite intracellulaire obligatoire (773)
Project FNS: 310030_147118
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KEELEY, Anthony, SOLDATI-FAVRE, Dominique. The glideosome: a molecular machine powering motility and host-cell invasion by Apicomplexa. In: Trends in Cell Biology, 2004, vol. 14, n° 10, p. 528-532. https://archive-ouverte.unige.ch/unige:78033

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Deposited on : 2015-12-02

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