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Rhomboid-like proteins in Apicomplexa: phylogeny and nomenclature

Dowse, Timothy J
Published in Trends in Parasitology. 2005, vol. 21, no. 6, p. 254-258
Abstract Rhomboids form a family of polytopic intramembrane serine proteases. In Toxoplasma gondii, an essential activity called microneme protein protease 1 (MPP1) cleaves secreted adhesive proteins within their transmembrane domains, at a site conserved in similar proteins of other Apicomplexa. Current evidence suggests that MPP1 is ubiquitous in the phylum and is encoded by a rhomboid gene. In this article, we present the current repertoire of rhomboid-like proteins in Apicomplexa using a nomenclature based on phylogenetic analyses.
Keywords Amino Acid SequenceAnimalsApicomplexa/classification/enzymology/geneticsCell Adhesion Molecules/chemistry/genetics/metabolismGene Expression ProfilingGenes, ProtozoanHost-Parasite InteractionsMembrane Proteins/chemistry/genetics/metabolismMolecular Sequence DataPhylogenyProtozoan Proteins/chemistry/genetics/metabolismSerine Endopeptidases/chemistry/genetics/metabolism
PMID: 15922242
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Research group Biologie d'un parasite intracellulaire obligatoire (773)
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DOWSE, Timothy J, SOLDATI-FAVRE, Dominique. Rhomboid-like proteins in Apicomplexa: phylogeny and nomenclature. In: Trends in Parasitology, 2005, vol. 21, n° 6, p. 254-258. doi: 10.1016/j.pt.2005.04.009 https://archive-ouverte.unige.ch/unige:78029

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Deposited on : 2015-12-02

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