UNIGE document Scientific Article
previous document  unige:77985  next document
add to browser collection
Title

The p11/S100A10 Light Chain of Annexin A2 Is Dispensable for Annexin A2 Association to Endosomes and Functions in Endosomal Transport
Authors
Morel, Etienne
Gruenberg, Jean
Published in PLOS ONE. 2007, vol. 2, no. 10, p. e1118
Abstract Annexin A2 is a peripheral membrane protein that belongs to the annexin family of Ca2+ and phospholipid-binding proteins. This protein, which plays a role in membrane organization and dynamics in particular along the endocytic pathway, exists as a heterotetrameric complex, consisting of two annexin A2 molecules bound via their N-termini to a dimer of p11/S100A10 light chains. The light chain, and thus presumably formation of the heterotetramer, was reported to control annexin A2 association to the plasma membrane and to cortical actin, as well as the distribution of recycling endosomes. However, the specific role of the light chain and the functions of monomeric versus heterotetrameric annexin A2 have remained elusive in the endocytic pathway.
Identifiers
Full text
Article (Published version) (1.2 MB) - public document Free access
Other version: http://dx.plos.org/10.1371/journal.pone.0001118
Structures
Faculté des sciences / Section de chimie et biochimie / Département de biochimie
Citation
(ISO format) 		MOREL, Etienne, GRUENBERG, Jean. The p11/S100A10 Light Chain of Annexin A2 Is Dispensable for Annexin A2 Association to Endosomes and Functions in Endosomal Transport. In: PLOS ONE, 2007, vol. 2, n° 10, p. e1118. https://archive-ouverte.unige.ch/unige:77985

137 hits

26 downloads

Contact an author

Update request

Update

Deposited on : 2015-12-01

Export document
Format :
Citation style :