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Scientific article
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The Redox Sensor TXNL1 Plays a Regulatory Role in Fluid Phase Endocytosis

Published inPloS one, vol. 2, no. 11, e1144
Publication date2007
Abstract

Small GTPases of the Rab family can cycle between a GTP- and a GDP-bound state and also between membrane and cytosol. The latter cycle is mediated by the Guanine Nucleotide Dissociation Inhibitor GDI, which can selectively extract GDP-bound Rab proteins from donor membranes, and then reload them on target membranes. In previous studies, we found that capture of the small GTPase Rab5, a key regulator of endocytic membrane traffic, by GDI is stimulated by oxidative stress via p38MAPK, resulting in increased fluid phase endocytosis.

Citation (ISO format)
FELBERBAUM-CORTI, Michela et al. The Redox Sensor TXNL1 Plays a Regulatory Role in Fluid Phase Endocytosis. In: PloS one, 2007, vol. 2, n° 11, p. e1144. doi: 10.1371/journal.pone.0001144
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ISSN of the journal1932-6203
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