UNIGE document Scientific Article
previous document  unige:77920  next document
add to browser collection

Serotonin-related pathways and developmental plasticity: relevance for psychiatric disorders

Published in Dialogues in clinical neuroscience. 2014, vol. 16, no. 1, p. 29-41
Abstract Risk for adult psychiatric disorders is partially determined by early-life alterations occurring during neural circuit formation and maturation. In this perspective, recent data show that the serotonin system regulates key cellular processes involved in the construction of cortical circuits. Translational data for rodents indicate that early-life serotonin dysregulation leads to a wide range of behavioral alterations, ranging from stress-related phenotypes to social deficits. Studies in humans have revealed that serotonin-related genetic variants interact with early-life stress to regulate stress-induced cortisol responsiveness and activate the neural circuits involved in mood and anxiety disorders. Emerging data demonstrate that early-life adversity induces epigenetic modifications in serotonin-related genes. Finally, recent findings reveal that selective serotonin reuptake inhibitors can reinstate juvenile-like forms of neural plasticity, thus allowing the erasure of long-lasting fear memories. These approaches are providing new insights on the biological mechanisms and clinical application of antidepressants.
Keywords AnimalsBrain/growth & developmentGene-Environment InteractionGenetic VariationHumansMental Disorders/genetics/metabolism/physiopathologyNeurogenesis/physiologyNeuronal Plasticity/physiologySerotonin/geneticsStress, Psychological/complications
PMID: 24733969
Full text
Article (Published version) (1.3 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Groupe Dayer Alexandre (Formation du circuit cortical) (875)
(ISO format)
DAYER, Alexandre. Serotonin-related pathways and developmental plasticity: relevance for psychiatric disorders. In: Dialogues in clinical neuroscience, 2014, vol. 16, n° 1, p. 29-41. https://archive-ouverte.unige.ch/unige:77920

319 hits



Deposited on : 2015-11-30

Export document
Format :
Citation style :