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Title

The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism
Authors
Jacobshagen, Moritz
Niquille, Mathieu
Chaumont-Dubel, Séverine
Marin, Philippe
Dayer, Alexandre
Published in Development. 2014, vol. 141, no. 17, p. 3370-3377
Abstract The formation of a laminar structure such as the mammalian neocortex relies on the coordinated migration of different subtypes of excitatory pyramidal neurons in specific layers. Cyclin-dependent kinase 5 (Cdk5) is a master regulator of pyramidal neuron migration. Recently, we have shown that Cdk5 binds to the serotonin 6 receptor (5-HT6R), a G protein-coupled receptor (GPCR). Here, we investigated the role of 5-HT6R in the positioning and migration of pyramidal neurons during mouse corticogenesis. We report that constitutive expression of 5-HT6R controls pyramidal neuron migration through an agonist-independent mechanism that requires Cdk5 activity. These data provide the first in vivo evidence of a role for constitutive activity at a GPCR in neocortical radial migration.
Keywords Animals — Cell Movement — Cerebral Cortex/cytology/metabolism — Cyclin-Dependent Kinase 5/metabolism — Down-Regulation — Female — HEK293 Cells — Humans — Ligands — Mice — Mice, Inbred C57BL — Neurogenesis — Neurons/cytology/metabolism — Pyramidal Cells/cytology/metabolism — Receptors, Serotonin/genetics/metabolism — Substrate Specificity
Identifiers
PMID: 25078650
Full text
Article (Published version) (1.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Research group Groupe Dayer Alexandre (Formation du circuit cortical) (875)
Citation
(ISO format) 		JACOBSHAGEN, Moritz et al. The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism. In: Development, 2014, vol. 141, n° 17, p. 3370-3377. doi: 10.1242/dev.108043 https://archive-ouverte.unige.ch/unige:77919

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Deposited on : 2015-11-30

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