UNIGE document Scientific Article
previous document  unige:77919  next document
add to browser collection
Title

The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism

Authors
Chaumont-Dubel, Séverine
Marin, Philippe
Published in Development. 2014, vol. 141, no. 17, p. 3370-3377
Abstract The formation of a laminar structure such as the mammalian neocortex relies on the coordinated migration of different subtypes of excitatory pyramidal neurons in specific layers. Cyclin-dependent kinase 5 (Cdk5) is a master regulator of pyramidal neuron migration. Recently, we have shown that Cdk5 binds to the serotonin 6 receptor (5-HT6R), a G protein-coupled receptor (GPCR). Here, we investigated the role of 5-HT6R in the positioning and migration of pyramidal neurons during mouse corticogenesis. We report that constitutive expression of 5-HT6R controls pyramidal neuron migration through an agonist-independent mechanism that requires Cdk5 activity. These data provide the first in vivo evidence of a role for constitutive activity at a GPCR in neocortical radial migration.
Keywords AnimalsCell MovementCerebral Cortex/cytology/metabolismCyclin-Dependent Kinase 5/metabolismDown-RegulationFemaleHEK293 CellsHumansLigandsMiceMice, Inbred C57BLNeurogenesisNeurons/cytology/metabolismPyramidal Cells/cytology/metabolismReceptors, Serotonin/genetics/metabolismSubstrate Specificity
Identifiers
PMID: 25078650
Full text
Article (Published version) (1.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Groupe Dayer Alexandre (Formation du circuit cortical) (875)
Citation
(ISO format)
JACOBSHAGEN, Moritz et al. The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism. In: Development, 2014, vol. 141, n° 17, p. 3370-3377. https://archive-ouverte.unige.ch/unige:77919

166 hits

3 downloads

Update

Deposited on : 2015-11-30

Export document
Format :
Citation style :