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Validation of a patient-specific one-dimensional model of the systemic arterial tree

Bohraus, Yvette
Stergiopulos, Nikos
Published in American journal of physiology. Heart and circulatory physiology. 2011, vol. 301, no. 3, p. H1173-1182
Abstract The aim of this study is to develop and validate a patient-specific distributed model of the systemic arterial tree. This model is built using geometric and hemodynamic data measured on a specific person and validated with noninvasive measurements of flow and pressure on the same person, providing thus a patient-specific model and validation. The systemic arterial tree geometry was obtained from MR angiographic measurements. A nonlinear viscoelastic constitutive law for the arterial wall is considered. Arterial wall distensibility is based on literature data and adapted to match the wave propagation velocity of the main arteries of the specific subject, which were estimated by pressure waves traveling time. The intimal shear stress is modeled using the Witzig-Womersley theory. Blood pressure is measured using applanation tonometry and flow rate using transcranial ultrasound and phase-contrast-MRI. The model predicts pressure and flow waveforms in good qualitative and quantitative agreement with the in vivo measurements, in terms of wave shape and specific wave features. Comparison with a generic one-dimensional model shows that the patient-specific model better predicts pressure and flow at specific arterial sites. These results obtained let us conclude that a patient-specific one-dimensional model of the arterial tree is able to predict well pressure and flow waveforms in the main systemic circulation, whereas this is not always the case for a generic one-dimensional model.
Keywords AdultArteries/anatomy & histology/physiologyBiomechanical PhenomenaBlood Flow VelocityBlood PressureElasticityHemodynamicsHumansMagnetic Resonance AngiographyManometryModels, AnatomicModels, CardiovascularNonlinear DynamicsPredictive Value of TestsRegional Blood FlowReproducibility of ResultsStress, MechanicalTime FactorsUltrasonography, Doppler, ColorVascular Resistance
PMID: 21622820
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REYMOND, Philippe et al. Validation of a patient-specific one-dimensional model of the systemic arterial tree. In: American journal of physiology. Heart and circulatory physiology, 2011, vol. 301, n° 3, p. H1173-1182. doi: 10.1152/ajpheart.00821.2010 https://archive-ouverte.unige.ch/unige:77891

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Deposited on : 2015-11-30

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