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New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity

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Published in Oncoimmunology. 2015, vol. 4, no. 5, p. e988476
Abstract Plasmacytoid dendritic cells (pDCs) are not only potent inflammatory cytokine producers but also function as antigen-presenting cells (APCs). We have shown that vaccination using CpG-B activated tumor antigen (Ag) presenting pDCs induce Th17 cells that promote intratumoral immune cell recruitment, including antitumor cytotoxic T lymphocytes CTLs. Therefore, strategies targeting both innate and adaptive pDC functions may improve antitumor T-cell immunity.
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PMID: 26155409
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Article (Published version) (252 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Pathologie et immunologie (906)
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GUERY, Leslie, HUGUES, Stéphanie. New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity. In: OncoImmunology, 2015, vol. 4, n° 5, p. e988476. https://archive-ouverte.unige.ch/unige:77874

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Deposited on : 2015-11-30

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